New and efficient bioactive glass compositions for controlling endodontic pathogens

Bruna L. Correia; Ana T. P. C. Gomes; Rita Noites; José M. F. Ferreira; Ana S. Duarte

doi:10.3390/nano12091577

New and efficient bioactive glass compositions for controlling endodontic pathogens

Bruna L. Correia^*, Ana T. P. C. Gomes^*, Rita Noites^*, José M. F. Ferreira^*, Ana S. Duarte^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

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Abstract

Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol–gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments (E. faecalis and C. albicans) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of E. faecalis after 48 h of incubation, and all BG samples have a significant effect on C. albicans survival.

Original language	English
Article number	1577
Number of pages	16
Journal	Nanomaterials
Volume	12
Issue number	9
DOIs	https://doi.org/10.3390/nano12091577
Publication status	Published - 1 May 2022

Keywords

Bioactive glass
Candida albicans
Enterococcus faecalis
Intracanal medication
Reinfection
Root canal treatment

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10.3390/nano12091577Licence: CC BY

43693106Final published version, 2.44 MBLicence: CC BY

http://hdl.handle.net/10400.14/37702Licence: CC BY

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title = "New and efficient bioactive glass compositions for controlling endodontic pathogens",

abstract = "Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol–gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments (E. faecalis and C. albicans) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of E. faecalis after 48 h of incubation, and all BG samples have a significant effect on C. albicans survival.",

keywords = "Bioactive glass, Candida albicans, Enterococcus faecalis, Intracanal medication, Reinfection, Root canal treatment",

author = "Correia, {Bruna L.} and Gomes, {Ana T. P. C.} and Rita Noites and Ferreira, {Jos{\'e} M. F.} and Duarte, {Ana S.}",

note = "Funding Information: This work was developed within the scope of the projects of the CICECO?Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019 and of the CIIS-UCP, Viseu, FCT Ref. UIDB/04279/2020. Thanks are also due to FCT and UCP for the CEEC institutional financing of Ana T.P.C. Gomes (CEECINST/00137/2018/CP1520/CT0022) and Ana Sofia Duarte (CEECINST/00137/ 2018/CP1520/CT0013). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/nano12091577",

language = "English",

volume = "12",

journal = "Nanomaterials",

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AU - Correia, Bruna L.

AU - Gomes, Ana T. P. C.

AU - Noites, Rita

AU - Ferreira, José M. F.

AU - Duarte, Ana S.

N1 - Funding Information: This work was developed within the scope of the projects of the CICECO?Aveiro Institute of Materials, FCT Ref. UID/CTM/50011/2019 and of the CIIS-UCP, Viseu, FCT Ref. UIDB/04279/2020. Thanks are also due to FCT and UCP for the CEEC institutional financing of Ana T.P.C. Gomes (CEECINST/00137/2018/CP1520/CT0022) and Ana Sofia Duarte (CEECINST/00137/ 2018/CP1520/CT0013). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol–gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments (E. faecalis and C. albicans) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of E. faecalis after 48 h of incubation, and all BG samples have a significant effect on C. albicans survival.

AB - Endodontic treatment aims to conserve teeth through removing infected tissue, disinfecting, and filling/sealing the root canal. One of the most important treatment steps is the removal of microorganisms to avoid reinfection and consequent tooth loss. Due to increased resistance to intracanal medications, new alternative procedures are needed. Thus, an intracanal medication is suggested using three bioactive glass (BG) compositions (BG1, BG2, and BG3) produced by the sol–gel method, with different molar contents of bactericidal oxides. The BGs were morphologically and physically characterized. Their ability to inhibit the growth of two oral pathogens responsible for the failure of endodontic treatments (E. faecalis and C. albicans) was also studied. The results suggest that BG2 and BG3 can inhibit the growth of E. faecalis after 48 h of incubation, and all BG samples have a significant effect on C. albicans survival.

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KW - Candida albicans

KW - Enterococcus faecalis

KW - Intracanal medication

KW - Reinfection

KW - Root canal treatment

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New and efficient bioactive glass compositions for controlling endodontic pathogens

Abstract

Keywords

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CEEC Institucional 2018 - CIIS - Professor Auxiliar 1 - ASD

CEEC Institucional 2018 - CIIS: Infeções orais crónicas: diagnóstico não invasivo e novas terapias

CIIS: Center for Interdisciplinary Research in Health

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New and efficient bioactive glass compositions for controlling endodontic pathogens

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

CEEC Institucional 2018 - CIIS - Professor Auxiliar 1 - ASD

CEEC Institucional 2018 - CIIS: Infeções orais crónicas: diagnóstico não invasivo e novas terapias

CIIS: Center for Interdisciplinary Research in Health

Cite this