New CTX‐M group conferring β‐lactam resistance: a compendium of phylogenetic insights from biochemical, molecular, and structural biology

Jacinta Mendonça, Carla Guedes, Carina Silva, Sara Sá, Marco Oliveira, Gustavo Accioly, Pilar Baylina*, Pedro Barata, Cláudia Pereira, Ruben Fernandes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The production of extended‐spectrum β‐lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX‐M enzymes appear as the most efficient in terms of dissemination in different epidemiological contexts. CTX‐M enzymes exhibit a striking plas-ticity, with a large number of allelic variants distributed in several sublineages, which can be associated with functional heterogeneity of clinical relevance. This observational analytical study provides an update of this family, currently with more than 200 variants described, from a phylogenetic, molecular, and structural point of view through homology in amino acid sequences. Our data, combined with described literature, provide phylogenetic and structural evidence of a new group. Thus, herein, we propose six groups among CTX‐M enzymes: the already stablished CTX‐M‐1, CTX‐M‐2, CTX‐M‐8, CTX‐M‐9, and CTX‐M‐25 clusters, as well as CTX‐M‐151 as the new cluster.
Original languageEnglish
Article number256
Number of pages16
JournalBiology
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2022

Keywords

  • CTX‐M β‐lactamases
  • CTX‐M‐151 new group
  • Extended‐spectrum β‐lactamases (ESBL)

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