TY - JOUR
T1 - New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents
T2 - synthesis and evaluation of analytical performance in the determination of iron in waters
AU - Moniz, Tânia
AU - Cunha-Silva, Luís
AU - Mesquita, Raquel B. R.
AU - Miranda, Joana L. A.
AU - Silva, André M. N.
AU - Silva, Ana M. G.
AU - Rangel, António O. S. S.
AU - Castro, Baltazar de
AU - Rangel, Maria
N1 - Funding Information:
This work received financial support from the European Union (FEDER funds through COMPETE) and National Funds (FCT, Fundação para a Ciência e Tecnologia), under the Partnership Agreement PT2020 through project UID/QUI/50006/2013-POCI/01/0145/FEDER/007265 (LAQV/REQUIMTE) and PTDC/AGRPRO/3515/2014-POCI-01-0145-FEDER-016599. Programa Operacional Regional do Norte (ON.2 – O Novo Norte), under the Quadro de Referência Estratégico Nacional (QREN) and funded by Fundo Europeu de Desenvolvimento Regional (Feder) NORTE-07-0124-FEDER-000066 and NORTE-01-0145-FEDER-000024. R.B.R. Mesquita thanks for the grant SFRH/BDP/112032/2015. The Bruker Avance III 400 spectrometer is part of the National NMR network and was purchased under the framework of the National Programme for Scientific Re-equipment, contract REDE/1517/RMN/2005, with funds from POCI 2010 (FEDER) and (FCT).
Funding Information:
This work received financial support from the European Union ( FEDER funds through COMPETE) and National Funds ( FCT , Fundação para a Ciência e Tecnologia), under the Partnership Agreement PT2020 through project UID/QUI/50006/2013-POCI/01/0145/FEDER/007265 (LAQV/REQUIMTE) and PTDC/AGRPRO/3515/2014-POCI-01-0145-FEDER-016599. Programa Operacional Regional do Norte (ON.2 – O Novo Norte), under the Quadro de Referência Estratégico Nacional (QREN) and funded by Fundo Europeu de Desenvolvimento Regional (Feder) NORTE-07-0124-FEDER-000066 and NORTE-01-0145-FEDER-000024 . R.B.R. Mesquita thanks for the grant SFRH /BDP/112032/2015. The Bruker Avance III 400 spectrometer is part of the National NMR network and was purchased under the framework of the National Programme for Scientific Re-equipment, contract REDE/1517/RMN/2005, with funds from POCI 2010 (FEDER) and (FCT).
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Three new hydrophilic 3-hydroxy-4-pyridinone chelators containing ether-derived substituents were prepared by a more sustainable synthetic protocol that involves the use of microwave heating and commercially available amines, allowing the successful production of highly water soluble chelators with improved reaction yields and reaction times. Compared with parent 3-hydroxy-4-pyridinone ligands, the new compounds were obtained faster and in higher amounts, facilitating the scale up of the synthesis, which is crucial to produce these ligands and their respective iron(III) complexes for many biological, analytical and agricultural applications. Ligands were fully characterized by 1H and 13C Nuclear Magnetic Resonance, High Resolution Mass Spectrometry and Single Crystal X-ray Diffraction and their performance in the analytical determination of iron(III) in water samples was evaluated by sequential injection methods. The results obtained are scientifically relevant, pointing out the potential of the new and straightforwardly synthesized ligands as analytical reagents for determination of iron(III).
AB - Three new hydrophilic 3-hydroxy-4-pyridinone chelators containing ether-derived substituents were prepared by a more sustainable synthetic protocol that involves the use of microwave heating and commercially available amines, allowing the successful production of highly water soluble chelators with improved reaction yields and reaction times. Compared with parent 3-hydroxy-4-pyridinone ligands, the new compounds were obtained faster and in higher amounts, facilitating the scale up of the synthesis, which is crucial to produce these ligands and their respective iron(III) complexes for many biological, analytical and agricultural applications. Ligands were fully characterized by 1H and 13C Nuclear Magnetic Resonance, High Resolution Mass Spectrometry and Single Crystal X-ray Diffraction and their performance in the analytical determination of iron(III) in water samples was evaluated by sequential injection methods. The results obtained are scientifically relevant, pointing out the potential of the new and straightforwardly synthesized ligands as analytical reagents for determination of iron(III).
KW - 3-Hydroxy-4-pyridinone
KW - Iron chelator
KW - Microwave assisted synthesis
KW - Sequential injection
KW - X-ray diffraction
UR - http://www.scopus.com/inward/record.url?scp=85059627781&partnerID=8YFLogxK
U2 - 10.1016/j.poly.2018.12.005
DO - 10.1016/j.poly.2018.12.005
M3 - Article
AN - SCOPUS:85059627781
SN - 0277-5387
VL - 160
SP - 145
EP - 156
JO - Polyhedron
JF - Polyhedron
ER -