New polymer-based reduction of plasma low density lipoproteins with an immobilized enzyme

R. Labeque; B. M. Clark; R. S. Lees; J. Ferreira; C. J.P. Mullon; R. Langer

New polymer-based reduction of plasma low density lipoproteins with an immobilized enzyme

R. Labeque^*, B. M. Clark, R. S. Lees, J. Ferreira, C. J.P. Mullon, R. Langer

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

1 Citation (Scopus)

Abstract

Over the past few years therapies making use of immobilized enzymes have been investigated. The authors have studied the potential of LDL removal from plasma by modification with immobilized phospholipase A₂ (PLA₂). PLA₂ are a class of ubiquitous enzymes that hydrolyze the sn-2 fatty acyl ester bond of phospholipids generating free fatty acids and lysophospholipids. PLA₂ have been shown to hydrolyze LDL core phospholipids. Considering that PLA₂-LDL might be degraded by the patient's own metabolic processes. The authors have developed an extracorporeal reactor containing immobilized PLA₂.

Original language	English
Pages (from-to)	720-725
Number of pages	6
Journal	Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
Volume	63
Publication status	Published - 1990
Externally published	Yes
Event	Proceedings of the ACS Division of Polymeric Materials: Science and Engineering - Washington, DC, USA Duration: 26 Aug 1990 → 31 Aug 1990

Cite this

@article{c1535e0f28fb490b8c54dfb5fab2ab2a,

title = "New polymer-based reduction of plasma low density lipoproteins with an immobilized enzyme",

abstract = "Over the past few years therapies making use of immobilized enzymes have been investigated. The authors have studied the potential of LDL removal from plasma by modification with immobilized phospholipase A2 (PLA2). PLA2 are a class of ubiquitous enzymes that hydrolyze the sn-2 fatty acyl ester bond of phospholipids generating free fatty acids and lysophospholipids. PLA2 have been shown to hydrolyze LDL core phospholipids. Considering that PLA2-LDL might be degraded by the patient's own metabolic processes. The authors have developed an extracorporeal reactor containing immobilized PLA2.",

author = "R. Labeque and Clark, {B. M.} and Lees, {R. S.} and J. Ferreira and Mullon, {C. J.P.} and R. Langer",

year = "1990",

language = "English",

volume = "63",

pages = "720--725",

journal = "Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering",

issn = "0743-0515",

note = "Proceedings of the ACS Division of Polymeric Materials: Science and Engineering ; Conference date: 26-08-1990 Through 31-08-1990",

}

New polymer-based reduction of plasma low density lipoproteins with an immobilized enzyme. / Labeque, R.; Clark, B. M.; Lees, R. S. et al.
In: Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, Vol. 63, 1990, p. 720-725.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - New polymer-based reduction of plasma low density lipoproteins with an immobilized enzyme

AU - Labeque, R.

AU - Clark, B. M.

AU - Lees, R. S.

AU - Ferreira, J.

AU - Mullon, C. J.P.

AU - Langer, R.

PY - 1990

Y1 - 1990

N2 - Over the past few years therapies making use of immobilized enzymes have been investigated. The authors have studied the potential of LDL removal from plasma by modification with immobilized phospholipase A2 (PLA2). PLA2 are a class of ubiquitous enzymes that hydrolyze the sn-2 fatty acyl ester bond of phospholipids generating free fatty acids and lysophospholipids. PLA2 have been shown to hydrolyze LDL core phospholipids. Considering that PLA2-LDL might be degraded by the patient's own metabolic processes. The authors have developed an extracorporeal reactor containing immobilized PLA2.

AB - Over the past few years therapies making use of immobilized enzymes have been investigated. The authors have studied the potential of LDL removal from plasma by modification with immobilized phospholipase A2 (PLA2). PLA2 are a class of ubiquitous enzymes that hydrolyze the sn-2 fatty acyl ester bond of phospholipids generating free fatty acids and lysophospholipids. PLA2 have been shown to hydrolyze LDL core phospholipids. Considering that PLA2-LDL might be degraded by the patient's own metabolic processes. The authors have developed an extracorporeal reactor containing immobilized PLA2.

UR - http://www.scopus.com/inward/record.url?scp=0025644093&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0025644093

SN - 0743-0515

VL - 63

SP - 720

EP - 725

JO - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering

JF - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering

T2 - Proceedings of the ACS Division of Polymeric Materials: Science and Engineering

Y2 - 26 August 1990 through 31 August 1990

ER -

New polymer-based reduction of plasma low density lipoproteins with an immobilized enzyme

Abstract

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