Next-generation probiotics

Joana Cristina Barbosa*, Daniela Machado, Diana Almeida, José Carlos Andrade, Adriano Brandelli, Ana Maria Gomes, Ana Cristina Freitas

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Citations (Scopus)


In the last years, the scientific community has recognized that specific microbial strains resident in the intestinal ecosystem play a key role in human health, participating in several functions beneficial to the host. Such microorganisms have been termed as next-generation probiotics and they are presently considered as food/nutraceutical supplements and biotherapeutic products. However, most of the next-generation probiotic candidates are nutritionally demanding and highly sensitive to aerobic conditions, which translates into several technological challenges concerning large-scale production and appeals to the development of suitable delivery systems able to promote viability and functionality of such probiotic strains. In this chapter, we will present an overall perspective of next-generation probiotics candidates in terms of their health beneficial effects, the delivery systems developed and employed to protect them, and related regulation framework and risk assessment targeting relevant criteria for commercialization in food and pharmaceutical markets.
Original languageEnglish
Title of host publicationProbiotics
Subtitle of host publicationadvanced food and health applications
EditorsAdriano Brandelli
PublisherAcademic Press Inc.
Number of pages20
ISBN (Electronic)9780323851701
ISBN (Print)9780323851701
Publication statusPublished - 6 Dec 2021


  • Biotherapeutics
  • Delivery systems
  • Dysbiosis
  • Gut microbiota
  • Novel foods
  • Probiotics


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