Novel insights into mitotic chromosome condensation

Ewa Piskadlo, Raquel A. Oliveira

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

The fidelity of mitosis is essential for life, and successful completion of this process relies on drastic changes in chromosome organization at the onset of nuclear division. The mechanisms that govern chromosome compaction at every cell division cycle are still far from full comprehension, yet recent studies provide novel insights into this problem, challenging classical views on mitotic chromosome assembly. Here, we briefly introduce various models for chromosome assembly and known factors involved in the condensation process (e.g. condensin complexes and topoisomerase II). We will then focus on a few selected studies that have recently brought novel insights into the mysterious way chromosomes are condensed during nuclear division.

Original languageEnglish
Article number1807
JournalF1000Research
Volume5
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Mitotic
  • Mitosis
  • Chromosome
  • Condensation

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