O uso de porfirinas em terapia fotodinâmica no tratamento da leishmaniose cutânea

Mônica M. Bastos; Núbia Boechat; Ana T.P.C. Gomes; Maria G.P.M.S. Neves; José A.S. Cavaleiro

doi:10.5935/1984-6835.20120021

O uso de porfirinas em terapia fotodinâmica no tratamento da leishmaniose cutânea

Translated title of the contribution: The use of porphyrins in photodynamic therapy of cutaneous leishmaniasis

Mônica M. Bastos^*, Núbia Boechat, Ana T.P.C. Gomes, Maria G.P.M.S. Neves, José A.S. Cavaleiro

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Leishmaniasis is a disease transmitted by protozoa of the genus Leishmania. Numerous species are responsible for the infection in humans, resulting in three clinical phenotypes. The therapeutic drug availability for treatment of this endemic disease is still limited and presents several problems. Photodynamic therapy (PDT) is presented as an alternative action for the treatment of cutaneous leishmaniasis (CL). Studies suggest that this therapy using porphyrins is relatively effective in the treatment of CL. However, data are still limited and PDT can not yet be recommended in clinical routine practice. Moreover, the mechanism of action of this promising therapy still needs to be investigated.

Translated title of the contribution	The use of porphyrins in photodynamic therapy of cutaneous leishmaniasis
Original language	Portuguese
Pages (from-to)	257-267
Number of pages	11
Journal	Revista Virtual de Quimica
Volume	4
Issue number	3
DOIs	https://doi.org/10.5935/1984-6835.20120021
Publication status	Published - 2012

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title = "O uso de porfirinas em terapia fotodin{\^a}mica no tratamento da leishmaniose cut{\^a}nea",

abstract = "Leishmaniasis is a disease transmitted by protozoa of the genus Leishmania. Numerous species are responsible for the infection in humans, resulting in three clinical phenotypes. The therapeutic drug availability for treatment of this endemic disease is still limited and presents several problems. Photodynamic therapy (PDT) is presented as an alternative action for the treatment of cutaneous leishmaniasis (CL). Studies suggest that this therapy using porphyrins is relatively effective in the treatment of CL. However, data are still limited and PDT can not yet be recommended in clinical routine practice. Moreover, the mechanism of action of this promising therapy still needs to be investigated.",

keywords = "Cutaneous leishmaniasis, Neglected diseases, Photodynamic therapy, Porphyrins",

author = "Bastos, {M{\^o}nica M.} and N{\'u}bia Boechat and Gomes, {Ana T.P.C.} and Neves, {Maria G.P.M.S.} and Cavaleiro, {Jos{\'e} A.S.}",

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T1 - O uso de porfirinas em terapia fotodinâmica no tratamento da leishmaniose cutânea

AU - Bastos, Mônica M.

AU - Boechat, Núbia

AU - Gomes, Ana T.P.C.

AU - Neves, Maria G.P.M.S.

AU - Cavaleiro, José A.S.

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AB - Leishmaniasis is a disease transmitted by protozoa of the genus Leishmania. Numerous species are responsible for the infection in humans, resulting in three clinical phenotypes. The therapeutic drug availability for treatment of this endemic disease is still limited and presents several problems. Photodynamic therapy (PDT) is presented as an alternative action for the treatment of cutaneous leishmaniasis (CL). Studies suggest that this therapy using porphyrins is relatively effective in the treatment of CL. However, data are still limited and PDT can not yet be recommended in clinical routine practice. Moreover, the mechanism of action of this promising therapy still needs to be investigated.

KW - Cutaneous leishmaniasis

KW - Neglected diseases

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KW - Porphyrins

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DO - 10.5935/1984-6835.20120021

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IS - 3

ER -

O uso de porfirinas em terapia fotodinâmica no tratamento da leishmaniose cutânea

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