On-hand tool for CKD monitoring: design of a couple of µPADs for ammonium and urea determination in saliva

Francisca T. S. M. Ferreira; António O. S. S. Rangel; Raquel B. R. Mesquita

On-hand tool for CKD monitoring: design of a couple of µPADs for ammonium and urea determination in saliva

Francisca T. S. M. Ferreira, António O. S. S. Rangel, Raquel B. R. Mesquita

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Abstract

Chronic Kidney Disease (CKD), is a condition in which the kidneys malfunction, causing the accumulation of metabolic toxins. Urea is a nitrogenous product of the protein metabolism by the urea cycle, resulting from the toxic NHx convertion. Since its primarily form of secretion is the kidney, urea is one of the most used biomarkers for kidney failure. Microfluidic paper-based analytical devices (μPADs) are a recent concept that has gained a lot of attention in the last few years as on-hand, point-of-care biosensors. These devices have gained a great interest since are capable of performing the analytical determinations in less time and with a more simpler, economic and user- friendly procedure. In this work, a couple of μPADs were developed for the determination of NHx and urea in saliva samples. The determination was based on color change of bromotymol blue indicator (BTB) after the ammonia diffusion through an hydrophobic membrane [1].

Original language	English
Title of host publication	Flow Analysis XV
Subtitle of host publication	book of abstratcs
Editors	Joanna Kozak, Anna Telk, Aneta Woźniakiewicz, Justyna Paluch
Place of Publication	Krakow
Publisher	Jagiellonian University
Pages	120-120
Number of pages	1
ISBN (Print)	9788396350411
Publication status	Published - 2022
Event	15th International Conference on Flow Analysis - Jagiellonian University, Krakow, Poland Duration: 26 Jun 2022 → 1 Jul 2022

Conference

Conference	15th International Conference on Flow Analysis
Abbreviated title	Flow Analysis XV
Country/Territory	Poland
City	Krakow
Period	26/06/22 → 1/07/22

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102534244Final published version, 379 KBLicence: CC BY

http://hdl.handle.net/10400.14/45778Licence: CC BY

Cite this

@inproceedings{c91ad10343bb4813a3e78ed27d3348a4,

title = "On-hand tool for CKD monitoring: design of a couple of µPADs for ammonium and urea determination in saliva",

abstract = "Chronic Kidney Disease (CKD), is a condition in which the kidneys malfunction, causing the accumulation of metabolic toxins. Urea is a nitrogenous product of the protein metabolism by the urea cycle, resulting from the toxic NHx convertion. Since its primarily form of secretion is the kidney, urea is one of the most used biomarkers for kidney failure. Microfluidic paper-based analytical devices (μPADs) are a recent concept that has gained a lot of attention in the last few years as on-hand, point-of-care biosensors. These devices have gained a great interest since are capable of performing the analytical determinations in less time and with a more simpler, economic and user- friendly procedure. In this work, a couple of μPADs were developed for the determination of NHx and urea in saliva samples. The determination was based on color change of bromotymol blue indicator (BTB) after the ammonia diffusion through an hydrophobic membrane [1].",

author = "Ferreira, {Francisca T. S. M.} and Rangel, {Ant{\'o}nio O. S. S.} and Mesquita, {Raquel B. R.}",

year = "2022",

language = "English",

isbn = "9788396350411",

pages = "120--120",

editor = "Joanna Kozak and Anna Telk and Aneta Wo{\'z}niakiewicz and Justyna Paluch",

booktitle = "Flow Analysis XV",

publisher = "Jagiellonian University",

note = "15th International Conference on Flow Analysis, Flow Analysis XV ; Conference date: 26-06-2022 Through 01-07-2022",

}

Ferreira, FTSM , Rangel, AOSS & Mesquita, RBR 2022, On-hand tool for CKD monitoring: design of a couple of µPADs for ammonium and urea determination in saliva. in J Kozak, A Telk, A Woźniakiewicz & J Paluch (eds), Flow Analysis XV: book of abstratcs. Jagiellonian University, Krakow, pp. 120-120, 15th International Conference on Flow Analysis, Krakow, Poland, 26/06/22. <http://hdl.handle.net/10400.14/45778>

On-hand tool for CKD monitoring: design of a couple of µPADs for ammonium and urea determination in saliva. / Ferreira, Francisca T. S. M.; Rangel, António O. S. S.; Mesquita, Raquel B. R.
Flow Analysis XV: book of abstratcs. ed. / Joanna Kozak; Anna Telk; Aneta Woźniakiewicz; Justyna Paluch. Krakow: Jagiellonian University, 2022. p. 120-120.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - On-hand tool for CKD monitoring

T2 - 15th International Conference on Flow Analysis

AU - Ferreira, Francisca T. S. M.

AU - Rangel, António O. S. S.

AU - Mesquita, Raquel B. R.

PY - 2022

Y1 - 2022

N2 - Chronic Kidney Disease (CKD), is a condition in which the kidneys malfunction, causing the accumulation of metabolic toxins. Urea is a nitrogenous product of the protein metabolism by the urea cycle, resulting from the toxic NHx convertion. Since its primarily form of secretion is the kidney, urea is one of the most used biomarkers for kidney failure. Microfluidic paper-based analytical devices (μPADs) are a recent concept that has gained a lot of attention in the last few years as on-hand, point-of-care biosensors. These devices have gained a great interest since are capable of performing the analytical determinations in less time and with a more simpler, economic and user- friendly procedure. In this work, a couple of μPADs were developed for the determination of NHx and urea in saliva samples. The determination was based on color change of bromotymol blue indicator (BTB) after the ammonia diffusion through an hydrophobic membrane [1].

AB - Chronic Kidney Disease (CKD), is a condition in which the kidneys malfunction, causing the accumulation of metabolic toxins. Urea is a nitrogenous product of the protein metabolism by the urea cycle, resulting from the toxic NHx convertion. Since its primarily form of secretion is the kidney, urea is one of the most used biomarkers for kidney failure. Microfluidic paper-based analytical devices (μPADs) are a recent concept that has gained a lot of attention in the last few years as on-hand, point-of-care biosensors. These devices have gained a great interest since are capable of performing the analytical determinations in less time and with a more simpler, economic and user- friendly procedure. In this work, a couple of μPADs were developed for the determination of NHx and urea in saliva samples. The determination was based on color change of bromotymol blue indicator (BTB) after the ammonia diffusion through an hydrophobic membrane [1].

M3 - Conference contribution

SN - 9788396350411

SP - 120

EP - 120

BT - Flow Analysis XV

A2 - Kozak, Joanna

A2 - Telk, Anna

A2 - Woźniakiewicz, Aneta

A2 - Paluch, Justyna

PB - Jagiellonian University

CY - Krakow

Y2 - 26 June 2022 through 1 July 2022

ER -

On-hand tool for CKD monitoring: design of a couple of µPADs for ammonium and urea determination in saliva

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