Opening new avenues for bioceramics: oscillatory flow reactors and upcoming technologies in skin-tissue engineering

Anabela Veiga; Filipa Castro; Fernando Rocha; Beatriz Bernardes; Marta M. Duarte; Ana Leite Oliveira

doi:10.4028/p-1f087p

Opening new avenues for bioceramics: oscillatory flow reactors and upcoming technologies in skin-tissue engineering

Anabela Veiga^*, Filipa Castro, Fernando Rocha, Beatriz Bernardes, Marta M. Duarte, Ana Leite Oliveira

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

An aging population and lifestyle-related practices increase the incidence of chronic diseases and consequently its costs. The increasing requests for efficient chronic wound care constitute an opportunity for the field of regenerative medicine but, at the same time, it represents a challenge due to the need to limit treatment costs. Calcium-based materials have enormous potential for skin applications, as calcium has an established role in the normal homeostasis of wounded skin and serves as a modulator in keratinocyte proliferation and differentiation. On the other hand, several natural biopolymers, as silk proteins are known for their antioxidant and moisturizing properties as well as a mitogenic influence on mammalian cells. In the present work, a cost-effective method using an oscillatory flow reactor to produce a calcium phosphate/sericin composite system with controlled properties is presented, to be applied in skin wound healing and regeneration. Future perspectives for the produced biomaterials are also addressed.

Original language	English
Pages (from-to)	79-87
Number of pages	9
Journal	Solid State Phenomena
Volume	339
DOIs	https://doi.org/10.4028/p-1f087p
Publication status	Published - 22 Dec 2022

Keywords

Calcium phosphate composites
Oscillatory flow reactors
Silk sericin
Skin tissue engineering
Supercritical fluids

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10.4028/p-1f087p

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title = "Opening new avenues for bioceramics: oscillatory flow reactors and upcoming technologies in skin-tissue engineering",

abstract = "An aging population and lifestyle-related practices increase the incidence of chronic diseases and consequently its costs. The increasing requests for efficient chronic wound care constitute an opportunity for the field of regenerative medicine but, at the same time, it represents a challenge due to the need to limit treatment costs. Calcium-based materials have enormous potential for skin applications, as calcium has an established role in the normal homeostasis of wounded skin and serves as a modulator in keratinocyte proliferation and differentiation. On the other hand, several natural biopolymers, as silk proteins are known for their antioxidant and moisturizing properties as well as a mitogenic influence on mammalian cells. In the present work, a cost-effective method using an oscillatory flow reactor to produce a calcium phosphate/sericin composite system with controlled properties is presented, to be applied in skin wound healing and regeneration. Future perspectives for the produced biomaterials are also addressed.",

keywords = "Calcium phosphate composites, Oscillatory flow reactors, Silk sericin, Skin tissue engineering, Supercritical fluids",

author = "Anabela Veiga and Filipa Castro and Fernando Rocha and Beatriz Bernardes and Duarte, {Marta M.} and Oliveira, {Ana Leite}",

note = "Funding Information: This work was financially supported by: National Funds through FCT (Foundation for Science and Technology) under the project UIDB/50016/2020 of the Centre for Biotechnology and Fine Chemistry - CBQF; and by LA/P/0045/2020 (ALiCE), UIDB/00511/2020 and UIDP/00511/2020 (LEPABE), funded by national funds through FCT/MCTES (PIDDAC). A. Veiga, B. G. Bernardes and M. Duarte gratefully acknowledges doctoral scholarship [2020.08683.BD], [2021.05717.BD], and [UI/BD/151391/2021] respectively, from FCT. Publisher Copyright: {\textcopyright} 2022 Trans Tech Publications Ltd, Switzerland.",

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T2 - oscillatory flow reactors and upcoming technologies in skin-tissue engineering

AU - Veiga, Anabela

AU - Castro, Filipa

AU - Rocha, Fernando

AU - Bernardes, Beatriz

AU - Duarte, Marta M.

AU - Oliveira, Ana Leite

N1 - Funding Information: This work was financially supported by: National Funds through FCT (Foundation for Science and Technology) under the project UIDB/50016/2020 of the Centre for Biotechnology and Fine Chemistry - CBQF; and by LA/P/0045/2020 (ALiCE), UIDB/00511/2020 and UIDP/00511/2020 (LEPABE), funded by national funds through FCT/MCTES (PIDDAC). A. Veiga, B. G. Bernardes and M. Duarte gratefully acknowledges doctoral scholarship [2020.08683.BD], [2021.05717.BD], and [UI/BD/151391/2021] respectively, from FCT. Publisher Copyright: © 2022 Trans Tech Publications Ltd, Switzerland.

PY - 2022/12/22

Y1 - 2022/12/22

N2 - An aging population and lifestyle-related practices increase the incidence of chronic diseases and consequently its costs. The increasing requests for efficient chronic wound care constitute an opportunity for the field of regenerative medicine but, at the same time, it represents a challenge due to the need to limit treatment costs. Calcium-based materials have enormous potential for skin applications, as calcium has an established role in the normal homeostasis of wounded skin and serves as a modulator in keratinocyte proliferation and differentiation. On the other hand, several natural biopolymers, as silk proteins are known for their antioxidant and moisturizing properties as well as a mitogenic influence on mammalian cells. In the present work, a cost-effective method using an oscillatory flow reactor to produce a calcium phosphate/sericin composite system with controlled properties is presented, to be applied in skin wound healing and regeneration. Future perspectives for the produced biomaterials are also addressed.

AB - An aging population and lifestyle-related practices increase the incidence of chronic diseases and consequently its costs. The increasing requests for efficient chronic wound care constitute an opportunity for the field of regenerative medicine but, at the same time, it represents a challenge due to the need to limit treatment costs. Calcium-based materials have enormous potential for skin applications, as calcium has an established role in the normal homeostasis of wounded skin and serves as a modulator in keratinocyte proliferation and differentiation. On the other hand, several natural biopolymers, as silk proteins are known for their antioxidant and moisturizing properties as well as a mitogenic influence on mammalian cells. In the present work, a cost-effective method using an oscillatory flow reactor to produce a calcium phosphate/sericin composite system with controlled properties is presented, to be applied in skin wound healing and regeneration. Future perspectives for the produced biomaterials are also addressed.

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KW - Supercritical fluids

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ER -

Opening new avenues for bioceramics: oscillatory flow reactors and upcoming technologies in skin-tissue engineering

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Keywords

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