Optimization of two biopolymer-based oral films for the delivery of bioactive molecules

Pedro M. Castro; Pedro Fonte; Ana Oliveira; Ana Raquel Madureira; Bruno Sarmento; Manuela E. Pintado

doi:10.1016/j.msec.2017.02.173

Optimization of two biopolymer-based oral films for the delivery of bioactive molecules

Pedro M. Castro, Pedro Fonte, Ana Oliveira, Ana Raquel Madureira, Bruno Sarmento, Manuela E. Pintado^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

An experimental design was established in order to optimize the mechanical properties of two oral film formulations intended for oral delivery of bioactive compounds. Carboxymethylcellulose (CMC) and gelatin type A (GelTA) were selected as polymeric matrix. Scanning electron microscopy revealed that caffeine crystals were homogeneously dispersed onto oral film matrix. Fourier-transform infrared analysis did not indicate formation of new chemical entities. USP modified dissolution assay revealed that GelTA was more effective in controlling caffeine release since maximum caffeine release (97.4% ± 0.95) after 20 min. On the other hand, CMC is better indicated for immediate release since maximum caffeine release (81.1% ± 2.14) occurred after 4 min. Simulation of gastrointestinal tract with ex vivo permeability assay was in accordance with USP dissolution assay (42.0% ± 7.79 and 15.3% ± 4.0 of caffeine released from CMC and GelTA oral films (OF), respectively, permeated porcine intestinal mucosa after 120 min). CMCOF and GelTAOF optimized formulations represent two suitable oral delivery systems for immediate and controlled release, respectively.

Original language	English
Pages (from-to)	171-180
Number of pages	10
Journal	Materials Science and Engineering C
Volume	76
DOIs	https://doi.org/10.1016/j.msec.2017.02.173
Publication status	Published - 1 Jul 2017

Keywords

Caffeine
Carboxymethylcellulose
Gelatin type A
Nutraceutical
Oral delivery
Oral films

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10.1016/j.msec.2017.02.173

http://hdl.handle.net/10400.14/23662

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title = "Optimization of two biopolymer-based oral films for the delivery of bioactive molecules",

abstract = "An experimental design was established in order to optimize the mechanical properties of two oral film formulations intended for oral delivery of bioactive compounds. Carboxymethylcellulose (CMC) and gelatin type A (GelTA) were selected as polymeric matrix. Scanning electron microscopy revealed that caffeine crystals were homogeneously dispersed onto oral film matrix. Fourier-transform infrared analysis did not indicate formation of new chemical entities. USP modified dissolution assay revealed that GelTA was more effective in controlling caffeine release since maximum caffeine release (97.4% ± 0.95) after 20 min. On the other hand, CMC is better indicated for immediate release since maximum caffeine release (81.1% ± 2.14) occurred after 4 min. Simulation of gastrointestinal tract with ex vivo permeability assay was in accordance with USP dissolution assay (42.0% ± 7.79 and 15.3% ± 4.0 of caffeine released from CMC and GelTA oral films (OF), respectively, permeated porcine intestinal mucosa after 120 min). CMCOF and GelTAOF optimized formulations represent two suitable oral delivery systems for immediate and controlled release, respectively.",

keywords = "Caffeine, Carboxymethylcellulose, Gelatin type A, Nutraceutical, Oral delivery, Oral films",

author = "Castro, {Pedro M.} and Pedro Fonte and Ana Oliveira and Madureira, {Ana Raquel} and Bruno Sarmento and Pintado, {Manuela E.}",

note = "Funding Information: Pedro Fonte thanks Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia (FCT), Portugal, for his PhD grant (SFRH/BD/78127/2011). Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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doi = "10.1016/j.msec.2017.02.173",

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AU - Castro, Pedro M.

AU - Fonte, Pedro

AU - Oliveira, Ana

AU - Madureira, Ana Raquel

AU - Sarmento, Bruno

AU - Pintado, Manuela E.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - An experimental design was established in order to optimize the mechanical properties of two oral film formulations intended for oral delivery of bioactive compounds. Carboxymethylcellulose (CMC) and gelatin type A (GelTA) were selected as polymeric matrix. Scanning electron microscopy revealed that caffeine crystals were homogeneously dispersed onto oral film matrix. Fourier-transform infrared analysis did not indicate formation of new chemical entities. USP modified dissolution assay revealed that GelTA was more effective in controlling caffeine release since maximum caffeine release (97.4% ± 0.95) after 20 min. On the other hand, CMC is better indicated for immediate release since maximum caffeine release (81.1% ± 2.14) occurred after 4 min. Simulation of gastrointestinal tract with ex vivo permeability assay was in accordance with USP dissolution assay (42.0% ± 7.79 and 15.3% ± 4.0 of caffeine released from CMC and GelTA oral films (OF), respectively, permeated porcine intestinal mucosa after 120 min). CMCOF and GelTAOF optimized formulations represent two suitable oral delivery systems for immediate and controlled release, respectively.

AB - An experimental design was established in order to optimize the mechanical properties of two oral film formulations intended for oral delivery of bioactive compounds. Carboxymethylcellulose (CMC) and gelatin type A (GelTA) were selected as polymeric matrix. Scanning electron microscopy revealed that caffeine crystals were homogeneously dispersed onto oral film matrix. Fourier-transform infrared analysis did not indicate formation of new chemical entities. USP modified dissolution assay revealed that GelTA was more effective in controlling caffeine release since maximum caffeine release (97.4% ± 0.95) after 20 min. On the other hand, CMC is better indicated for immediate release since maximum caffeine release (81.1% ± 2.14) occurred after 4 min. Simulation of gastrointestinal tract with ex vivo permeability assay was in accordance with USP dissolution assay (42.0% ± 7.79 and 15.3% ± 4.0 of caffeine released from CMC and GelTA oral films (OF), respectively, permeated porcine intestinal mucosa after 120 min). CMCOF and GelTAOF optimized formulations represent two suitable oral delivery systems for immediate and controlled release, respectively.

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KW - Gelatin type A

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Optimization of two biopolymer-based oral films for the delivery of bioactive molecules

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Keywords

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