Oral intake of carboxymethyl-glucan (CM-G) from yeast (Saccharomyces uvarum) reduces malondialdehyde levels in healthy men

Vilma Barbosa Da Silva Araújo, Adma Nadja Ferreira De Melo, Neyrijane Targino De Souza, Vânia Maria Barboza Da Silva, Raul H. Castro-Gomez, Alexandre Sérgio Silva, Evandro Leite De Souza, Marciane Magnani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1→3)(1→6) glucan, a well-known immunostimulant and antioxidant compound. In this experimental, randomized and placebo-controlled study, the effects of oral CM-G intake over a 60-day period on the peripheral blood, cholesterol, glycemic index and malondialdehyde (MDA) levels of healthy men was assessed. The CM-G was obtained from spent brewer's yeast (S. uvarum) with DS 0.8 and molecular weight of 2.2 × 105 Da. Following CM-G administration, no changes were observed in red and white blood cell, hematocrit, hemoglobin and platelet counts, or in cholesterol and glycemic indices. After 30 days of CM-G administration, the MDA levels decreased significantly (p ≤ 0.05) in men receiving CM-G. The results showed for the first time that CM-G may act as an adjuvant in preventing oxidative damage in healthy humans.

Original languageEnglish
Pages (from-to)14950-14958
Number of pages9
JournalMolecules
Volume20
Issue number8
DOIs
Publication statusPublished - 1 Aug 2015
Externally publishedYes

Keywords

  • Blood cells
  • Carboxymethyl-glucan
  • Glucan-derivatives
  • Malondialdehyde

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