TY - JOUR
T1 - Oral intake of carboxymethyl-glucan (CM-G) from yeast (Saccharomyces uvarum) reduces malondialdehyde levels in healthy men
AU - Da Silva Araújo, Vilma Barbosa
AU - De Melo, Adma Nadja Ferreira
AU - De Souza, Neyrijane Targino
AU - Da Silva, Vânia Maria Barboza
AU - Castro-Gomez, Raul H.
AU - Silva, Alexandre Sérgio
AU - De Souza, Evandro Leite
AU - Magnani, Marciane
N1 - Publisher Copyright:
© 2015 by the authors.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1→3)(1→6) glucan, a well-known immunostimulant and antioxidant compound. In this experimental, randomized and placebo-controlled study, the effects of oral CM-G intake over a 60-day period on the peripheral blood, cholesterol, glycemic index and malondialdehyde (MDA) levels of healthy men was assessed. The CM-G was obtained from spent brewer's yeast (S. uvarum) with DS 0.8 and molecular weight of 2.2 × 105 Da. Following CM-G administration, no changes were observed in red and white blood cell, hematocrit, hemoglobin and platelet counts, or in cholesterol and glycemic indices. After 30 days of CM-G administration, the MDA levels decreased significantly (p ≤ 0.05) in men receiving CM-G. The results showed for the first time that CM-G may act as an adjuvant in preventing oxidative damage in healthy humans.
AB - Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1→3)(1→6) glucan, a well-known immunostimulant and antioxidant compound. In this experimental, randomized and placebo-controlled study, the effects of oral CM-G intake over a 60-day period on the peripheral blood, cholesterol, glycemic index and malondialdehyde (MDA) levels of healthy men was assessed. The CM-G was obtained from spent brewer's yeast (S. uvarum) with DS 0.8 and molecular weight of 2.2 × 105 Da. Following CM-G administration, no changes were observed in red and white blood cell, hematocrit, hemoglobin and platelet counts, or in cholesterol and glycemic indices. After 30 days of CM-G administration, the MDA levels decreased significantly (p ≤ 0.05) in men receiving CM-G. The results showed for the first time that CM-G may act as an adjuvant in preventing oxidative damage in healthy humans.
KW - Blood cells
KW - Carboxymethyl-glucan
KW - Glucan-derivatives
KW - Malondialdehyde
UR - http://www.scopus.com/inward/record.url?scp=84941236792&partnerID=8YFLogxK
U2 - 10.3390/molecules200814950
DO - 10.3390/molecules200814950
M3 - Article
C2 - 26287149
SN - 1420-3049
VL - 20
SP - 14950
EP - 14958
JO - Molecules
JF - Molecules
IS - 8
ER -