Oral mucositis management in children under cancer treatment: a systematic review

Ricardo Braguês, Maria Francisca Marvão, Patrícia Correia, Raquel M. Silva*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as cryotherapy, low-level laser therapy, and natural compounds for this condition. The aim of this systematic review was to identify and compare therapies for the management of cancer treatment-induced oral mucositis in pediatric patients. From 2655 articles obtained in initial searches, 39 articles were considered in this systematic review, after applying inclusion/exclusion criteria. Low-level laser therapy, palifermin, honey, and zinc demonstrated reductions in oral mucositis incidence, duration, severity, and pain reported by the patient. Although there are several therapies in place for the prevention and treatment of oral mucositis in children, evidence of their efficacy is still inconclusive to establish accurate clinical protocols.

Original languageEnglish
Article number1548
Number of pages16
JournalCancers
Volume16
Issue number8
DOIs
Publication statusPublished - 18 Apr 2024

Keywords

  • Calcium phosphate
  • Honey
  • Low-level laser therapy
  • Oral mucositis
  • Palifermin
  • Pediatric cancer
  • Prevention
  • Therapeutics
  • Zinc

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