OralCard: a bioinformatic tool for the study of oral proteome

Joel P. Arrais*, Nuno Rosa, José Melo, Edgar D. Coelho, Diana Amaral, Maria José Correia, Marlene Barros, José Luís Oliveira

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Objectives: The molecular complexity of the human oral cavity can only be clarified through identification of components that participate within it. However current proteomic techniques produce high volumes of information that are dispersed over several online databases. Collecting all of this data and using an integrative approach capable of identifying unknown associations is still an unsolved problem. This is the main motivation for this work. Results: We present the online bioinformatic tool OralCard, which comprises results from 55 manually curated articles reflecting the oral molecular ecosystem (OralPhysiOme). It comprises experimental information available from the oral proteome both of human (OralOme) and microbial origin (MicroOralOme) structured in protein, disease and organism. Conclusions: This tool is a key resource for researchers to understand the molecular foundations implicated in biology and disease mechanisms of the oral cavity. The usefulness of this tool is illustrated with the analysis of the oral proteome associated with diabetes melitus type 2. OralCard is available at http://bioinformatics.ua.pt/oralcard.
Original languageEnglish
Pages (from-to)762-772
Number of pages11
JournalArchives of Oral Biology
Volume58
Issue number7
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Diabetes melitus
  • Microbiome
  • Oral proteome
  • OralCard

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