Osteogenic effect of tricalcium phosphate substituted by magnesium associated with Genderm® membrane in rat calvarial defect model

Neusa M. F. Costa*, Debora H. Yassuda, Marcia S. Sader, Gustavo V. O. Fernandes, Glória D. A. Soares, José M. Granjeiro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Beta-tricalcium phosphate (β-TCP) is one of the most widely employed bioresorbable materials for bone repair since it shows excellent biological compatibility, osteoconductivity and resorbability. The incorporation of divalent cations such as magnesium onto the β-TCP structure (β-TCMP) may improve the biological response to the material through the release of bioactive ions. The objective of this study was to evaluate, on a rat calvarial critical size grafting model, the bone regeneration process using β-TCP and β-TMCP granules by histomorphometric analysis. Results demonstrated that six months after bone grafting, the association of GBR (guided bone regeneration) using a membrane (GenDerm®) and granules of β-TCP and β-TCMP significantly improves bone repair in the treatment of critical-size defect in rat skulls, in comparison to untreated defects or GBR alone, leading to a bone level approximately four to five-fold greater than in the blood clot group. The β-TCMP + GenDerm® membrane group presented 40.5% of the defect area filled by newly-formed bone, even at the central part of the defect, rather than only at the border, as seen in the other experimental groups.
Original languageEnglish
Pages (from-to)63-71
Number of pages9
JournalMaterials Science and Engineering C
Volume61
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

Keywords

  • Bone substitutes
  • Guided bone regeneration
  • Magnesium-substituted tricalcium phosphate
  • β-Tricalcium phosphate

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