TY - JOUR
T1 - Osteogenic effect of tricalcium phosphate substituted by magnesium associated with Genderm® membrane in rat calvarial defect model
AU - Costa, Neusa M. F.
AU - Yassuda, Debora H.
AU - Sader, Marcia S.
AU - Fernandes, Gustavo V. O.
AU - Soares, Glória D. A.
AU - Granjeiro, José M.
N1 - Funding Information:
The authors acknowledge the financial support given by CAPES-COFECUB (628/09), CNPq ( 304.435/2011-2 ) and FAPERJ ( E-26/103.008/2011 ).
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Beta-tricalcium phosphate (β-TCP) is one of the most widely employed bioresorbable materials for bone repair since it shows excellent biological compatibility, osteoconductivity and resorbability. The incorporation of divalent cations such as magnesium onto the β-TCP structure (β-TCMP) may improve the biological response to the material through the release of bioactive ions. The objective of this study was to evaluate, on a rat calvarial critical size grafting model, the bone regeneration process using β-TCP and β-TMCP granules by histomorphometric analysis. Results demonstrated that six months after bone grafting, the association of GBR (guided bone regeneration) using a membrane (GenDerm®) and granules of β-TCP and β-TCMP significantly improves bone repair in the treatment of critical-size defect in rat skulls, in comparison to untreated defects or GBR alone, leading to a bone level approximately four to five-fold greater than in the blood clot group. The β-TCMP + GenDerm® membrane group presented 40.5% of the defect area filled by newly-formed bone, even at the central part of the defect, rather than only at the border, as seen in the other experimental groups.
AB - Beta-tricalcium phosphate (β-TCP) is one of the most widely employed bioresorbable materials for bone repair since it shows excellent biological compatibility, osteoconductivity and resorbability. The incorporation of divalent cations such as magnesium onto the β-TCP structure (β-TCMP) may improve the biological response to the material through the release of bioactive ions. The objective of this study was to evaluate, on a rat calvarial critical size grafting model, the bone regeneration process using β-TCP and β-TMCP granules by histomorphometric analysis. Results demonstrated that six months after bone grafting, the association of GBR (guided bone regeneration) using a membrane (GenDerm®) and granules of β-TCP and β-TCMP significantly improves bone repair in the treatment of critical-size defect in rat skulls, in comparison to untreated defects or GBR alone, leading to a bone level approximately four to five-fold greater than in the blood clot group. The β-TCMP + GenDerm® membrane group presented 40.5% of the defect area filled by newly-formed bone, even at the central part of the defect, rather than only at the border, as seen in the other experimental groups.
KW - Bone substitutes
KW - Guided bone regeneration
KW - Magnesium-substituted tricalcium phosphate
KW - β-Tricalcium phosphate
UR - http://www.scopus.com/inward/record.url?scp=84954228967&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2015.12.003
DO - 10.1016/j.msec.2015.12.003
M3 - Article
C2 - 26838825
AN - SCOPUS:84954228967
SN - 0928-4931
VL - 61
SP - 63
EP - 71
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -