Pernicious anaemia with normal vitamin B12

João Tavares; Bernardo Baptista; Bebiana Gonçalves; Alexandra Bayão Horta

doi:10.12890/2019_001045

Pernicious anaemia with normal vitamin B12

João Tavares, Bernardo Baptista, Bebiana Gonçalves, Alexandra Bayão Horta

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A 49-year-old female patient presented to our hospital with asthenia, odynophagia, low grade fever, worsening symptoms of chronic depression, and symmetric leg paresthesias. Investigations showed macrocytic anaemia, leucopenia, thrombocytopenia, high lactate dehydrogenase levels and a normal Coombs test. Trilineage dysplasia was detected in the bone marrow biopsy specimen. The diagnostic work-up led us to the diagnosis of pernicious anaemia with a spuriously normal value of vitamin B12 and high titres of anti-intrinsic factor autoantibodies. This case highlights the importance of considering vitamin B12 deficiency in the differential diagnosis of myelodysplasia, even when vitamin B12 levels seem to be normal.

Original language	English
Journal	European Journal of Case Reports in Internal Medicine
Volume	6
Issue number	2
DOIs	https://doi.org/10.12890/2019_001045
Publication status	Published - 2019
Externally published	Yes

Keywords

Anti-intrinsic factor antibodies
Myelodysplastic syndrome
Pernicious anaemia
Spuriously normal vitamin B12
Vitamin B12 deficiency

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10.12890/2019_001045Licence: CC BY-NC-ND

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title = "Pernicious anaemia with normal vitamin B12",

abstract = "A 49-year-old female patient presented to our hospital with asthenia, odynophagia, low grade fever, worsening symptoms of chronic depression, and symmetric leg paresthesias. Investigations showed macrocytic anaemia, leucopenia, thrombocytopenia, high lactate dehydrogenase levels and a normal Coombs test. Trilineage dysplasia was detected in the bone marrow biopsy specimen. The diagnostic work-up led us to the diagnosis of pernicious anaemia with a spuriously normal value of vitamin B12 and high titres of anti-intrinsic factor autoantibodies. This case highlights the importance of considering vitamin B12 deficiency in the differential diagnosis of myelodysplasia, even when vitamin B12 levels seem to be normal.",

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doi = "10.12890/2019_001045",

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T1 - Pernicious anaemia with normal vitamin B12

AU - Tavares, João

AU - Baptista, Bernardo

AU - Gonçalves, Bebiana

AU - Horta, Alexandra Bayão

N1 - Publisher Copyright: © EFIM 2019.

PY - 2019

Y1 - 2019

N2 - A 49-year-old female patient presented to our hospital with asthenia, odynophagia, low grade fever, worsening symptoms of chronic depression, and symmetric leg paresthesias. Investigations showed macrocytic anaemia, leucopenia, thrombocytopenia, high lactate dehydrogenase levels and a normal Coombs test. Trilineage dysplasia was detected in the bone marrow biopsy specimen. The diagnostic work-up led us to the diagnosis of pernicious anaemia with a spuriously normal value of vitamin B12 and high titres of anti-intrinsic factor autoantibodies. This case highlights the importance of considering vitamin B12 deficiency in the differential diagnosis of myelodysplasia, even when vitamin B12 levels seem to be normal.

AB - A 49-year-old female patient presented to our hospital with asthenia, odynophagia, low grade fever, worsening symptoms of chronic depression, and symmetric leg paresthesias. Investigations showed macrocytic anaemia, leucopenia, thrombocytopenia, high lactate dehydrogenase levels and a normal Coombs test. Trilineage dysplasia was detected in the bone marrow biopsy specimen. The diagnostic work-up led us to the diagnosis of pernicious anaemia with a spuriously normal value of vitamin B12 and high titres of anti-intrinsic factor autoantibodies. This case highlights the importance of considering vitamin B12 deficiency in the differential diagnosis of myelodysplasia, even when vitamin B12 levels seem to be normal.

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KW - Myelodysplastic syndrome

KW - Pernicious anaemia

KW - Spuriously normal vitamin B12

KW - Vitamin B12 deficiency

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JO - European Journal of Case Reports in Internal Medicine

JF - European Journal of Case Reports in Internal Medicine

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Pernicious anaemia with normal vitamin B12

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