Phthalic anhydride esterified chicha gum: characterization and antibacterial activity

Solranny Carla Cavalcante Costa Silva; Elton Marks Araujo Braz; Carla Adriana Rodrigues Sousa Brito; Michel Muálem Moraes Alves; Fernando Aécio Amorim Carvalho; Humberto Medeiros Barreto; Ana Leite Oliveira; Durcilene Alves Silva; Edson C. Silva-Filho

doi:10.1016/j.carbpol.2020.117077

Phthalic anhydride esterified chicha gum: characterization and antibacterial activity

Solranny Carla Cavalcante Costa Silva, Elton Marks Araujo Braz, Carla Adriana Rodrigues Sousa Brito, Michel Muálem Moraes Alves, Fernando Aécio Amorim Carvalho, Humberto Medeiros Barreto, Ana Leite Oliveira, Durcilene Alves Silva, Edson C. Silva-Filho^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The objective of this research was to modify chicha gum with phthalic anhydride to obtain a new biologically active material. The chemical modification of the gum structure was proven through FTIR, elemental analysis, XRD, TG, and DSC. The derived materials demonstrated excellent inhibitory effect against P. aeruginosa and K. pneumoniae species (rating 100% inhibition) and could also inhibit Escherichia coli growth. The best antimicrobial activity observed for the derivatives suggests that chicha gum hydrophobization due to the addition of phthalic groups improved the interaction of these derivatives with bacterial cell wall components. On the other hand, the derivatives increased CC50 in macrophages but did not present acute toxicity or hemolytic activity, indicating that they are promising for use in prophylaxis or treatment of infections caused by Gram-negative bacteria.

Original language	English
Article number	117077
Pages (from-to)	1-11
Number of pages	11
Journal	Carbohydrate Polymers
Volume	251
DOIs	https://doi.org/10.1016/j.carbpol.2020.117077
Publication status	Published - 1 Jan 2021

Keywords

Antimicrobial activity
Chemical modification
Gram-negative
Sterculia striata gum

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10.1016/j.carbpol.2020.117077

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Silva, Solranny Carla Cavalcante Costa ; Braz, Elton Marks Araujo ; Brito, Carla Adriana Rodrigues Sousa ; Alves, Michel Muálem Moraes ; Carvalho, Fernando Aécio Amorim ; Barreto, Humberto Medeiros ; Oliveira, Ana Leite ; Silva, Durcilene Alves ; Silva-Filho, Edson C. / Phthalic anhydride esterified chicha gum : characterization and antibacterial activity. In: Carbohydrate Polymers. 2021 ; Vol. 251. pp. 1-11.

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title = "Phthalic anhydride esterified chicha gum: characterization and antibacterial activity",

abstract = "The objective of this research was to modify chicha gum with phthalic anhydride to obtain a new biologically active material. The chemical modification of the gum structure was proven through FTIR, elemental analysis, XRD, TG, and DSC. The derived materials demonstrated excellent inhibitory effect against P. aeruginosa and K. pneumoniae species (rating 100% inhibition) and could also inhibit Escherichia coli growth. The best antimicrobial activity observed for the derivatives suggests that chicha gum hydrophobization due to the addition of phthalic groups improved the interaction of these derivatives with bacterial cell wall components. On the other hand, the derivatives increased CC50 in macrophages but did not present acute toxicity or hemolytic activity, indicating that they are promising for use in prophylaxis or treatment of infections caused by Gram-negative bacteria.",

keywords = "Antimicrobial activity, Chemical modification, Gram-negative, Sterculia striata gum",

author = "Silva, {Solranny Carla Cavalcante Costa} and Braz, {Elton Marks Araujo} and Brito, {Carla Adriana Rodrigues Sousa} and Alves, {Michel Mu{\'a}lem Moraes} and Carvalho, {Fernando A{\'e}cio Amorim} and Barreto, {Humberto Medeiros} and Oliveira, {Ana Leite} and Silva, {Durcilene Alves} and Silva-Filho, {Edson C.}",

year = "2021",

month = jan,

day = "1",

doi = "10.1016/j.carbpol.2020.117077",

language = "English",

volume = "251",

pages = "1--11",

journal = "Carbohydrate Polymers",

issn = "0144-8617",

publisher = "Elsevier Ltd.",

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Phthalic anhydride esterified chicha gum : characterization and antibacterial activity. / Silva, Solranny Carla Cavalcante Costa; Braz, Elton Marks Araujo; Brito, Carla Adriana Rodrigues Sousa; Alves, Michel Muálem Moraes; Carvalho, Fernando Aécio Amorim; Barreto, Humberto Medeiros; Oliveira, Ana Leite; Silva, Durcilene Alves; Silva-Filho, Edson C.

In: Carbohydrate Polymers, Vol. 251, 117077, 01.01.2021, p. 1-11.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Phthalic anhydride esterified chicha gum

T2 - characterization and antibacterial activity

AU - Silva, Solranny Carla Cavalcante Costa

AU - Braz, Elton Marks Araujo

AU - Brito, Carla Adriana Rodrigues Sousa

AU - Alves, Michel Muálem Moraes

AU - Carvalho, Fernando Aécio Amorim

AU - Barreto, Humberto Medeiros

AU - Oliveira, Ana Leite

AU - Silva, Durcilene Alves

AU - Silva-Filho, Edson C.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - The objective of this research was to modify chicha gum with phthalic anhydride to obtain a new biologically active material. The chemical modification of the gum structure was proven through FTIR, elemental analysis, XRD, TG, and DSC. The derived materials demonstrated excellent inhibitory effect against P. aeruginosa and K. pneumoniae species (rating 100% inhibition) and could also inhibit Escherichia coli growth. The best antimicrobial activity observed for the derivatives suggests that chicha gum hydrophobization due to the addition of phthalic groups improved the interaction of these derivatives with bacterial cell wall components. On the other hand, the derivatives increased CC50 in macrophages but did not present acute toxicity or hemolytic activity, indicating that they are promising for use in prophylaxis or treatment of infections caused by Gram-negative bacteria.

AB - The objective of this research was to modify chicha gum with phthalic anhydride to obtain a new biologically active material. The chemical modification of the gum structure was proven through FTIR, elemental analysis, XRD, TG, and DSC. The derived materials demonstrated excellent inhibitory effect against P. aeruginosa and K. pneumoniae species (rating 100% inhibition) and could also inhibit Escherichia coli growth. The best antimicrobial activity observed for the derivatives suggests that chicha gum hydrophobization due to the addition of phthalic groups improved the interaction of these derivatives with bacterial cell wall components. On the other hand, the derivatives increased CC50 in macrophages but did not present acute toxicity or hemolytic activity, indicating that they are promising for use in prophylaxis or treatment of infections caused by Gram-negative bacteria.

KW - Antimicrobial activity

KW - Chemical modification

KW - Gram-negative

KW - Sterculia striata gum

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M3 - Article

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SP - 1

EP - 11

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

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ER -

Phthalic anhydride esterified chicha gum: characterization and antibacterial activity

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Keywords

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CBQF Multianual Funding: Centre for Biotechnology and Fine Chemistry

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Phthalic anhydride esterified chicha gum: characterization and antibacterial activity

Abstract

Keywords

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CBQF Multianual Funding: Centre for Biotechnology and Fine Chemistry

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