Phthalic anhydride esterified chicha gum: characterization and antibacterial activity

Solranny Carla Cavalcante Costa Silva, Elton Marks Araujo Braz, Carla Adriana Rodrigues Sousa Brito, Michel Muálem Moraes Alves, Fernando Aécio Amorim Carvalho, Humberto Medeiros Barreto, Ana Leite Oliveira, Durcilene Alves Silva, Edson C. Silva-Filho*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The objective of this research was to modify chicha gum with phthalic anhydride to obtain a new biologically active material. The chemical modification of the gum structure was proven through FTIR, elemental analysis, XRD, TG, and DSC. The derived materials demonstrated excellent inhibitory effect against P. aeruginosa and K. pneumoniae species (rating 100% inhibition) and could also inhibit Escherichia coli growth. The best antimicrobial activity observed for the derivatives suggests that chicha gum hydrophobization due to the addition of phthalic groups improved the interaction of these derivatives with bacterial cell wall components. On the other hand, the derivatives increased CC50 in macrophages but did not present acute toxicity or hemolytic activity, indicating that they are promising for use in prophylaxis or treatment of infections caused by Gram-negative bacteria.
Original languageEnglish
Article number117077
Pages (from-to)1-11
Number of pages11
JournalCarbohydrate Polymers
Volume251
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • Antimicrobial activity
  • Chemical modification
  • Gram-negative
  • Sterculia striata gum

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