TY - JOUR
T1 - Phthalic anhydride esterified chicha gum
T2 - characterization and antibacterial activity
AU - Silva, Solranny Carla Cavalcante Costa
AU - Braz, Elton Marks Araujo
AU - Brito, Carla Adriana Rodrigues Sousa
AU - Alves, Michel Muálem Moraes
AU - Carvalho, Fernando Aécio Amorim
AU - Barreto, Humberto Medeiros
AU - Oliveira, Ana Leite
AU - Silva, Durcilene Alves
AU - Silva-Filho, Edson C.
N1 - Funding Information:
The authors thank the S tate University of Piauí (UESPI) , the F ederal University of Piauí (UFPI) , and the S chool of Biotechnology of the Center for Biotechnology and Fine Chemistry (CBQF) of the Catholic University of Porto for providing work research conditions. The project was supported by National Funds from FCT - Fundação para a Ciência e a Tecnologia through project UID/Multi/50016/2019, C oordination of Superior Level Staff Improvement, and the Brazilian National Council for Scientific and Technological Development ( 306176/2019-0; 408635/2016-9 and 307460/2016-9 ).
Funding Information:
The authors thank the State University of Piau? (UESPI), the Federal University of Piau? (UFPI), and the School of Biotechnology of the Center for Biotechnology and Fine Chemistry (CBQF) of the Catholic University of Portofor providing work research conditions. The project was supported by National Funds from FCT - Funda??o para a Ci?ncia e a Tecnologia through project UID/Multi/50016/2019, Coordination of Superior Level Staff Improvement, and the Brazilian National Council for Scientific and Technological Development (306176/2019-0;408635/2016-9 and 307460/2016-9).
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/1/1
Y1 - 2021/1/1
N2 - The objective of this research was to modify chicha gum with phthalic anhydride to obtain a new biologically active material. The chemical modification of the gum structure was proven through FTIR, elemental analysis, XRD, TG, and DSC. The derived materials demonstrated excellent inhibitory effect against P. aeruginosa and K. pneumoniae species (rating 100% inhibition) and could also inhibit Escherichia coli growth. The best antimicrobial activity observed for the derivatives suggests that chicha gum hydrophobization due to the addition of phthalic groups improved the interaction of these derivatives with bacterial cell wall components. On the other hand, the derivatives increased CC50 in macrophages but did not present acute toxicity or hemolytic activity, indicating that they are promising for use in prophylaxis or treatment of infections caused by Gram-negative bacteria.
AB - The objective of this research was to modify chicha gum with phthalic anhydride to obtain a new biologically active material. The chemical modification of the gum structure was proven through FTIR, elemental analysis, XRD, TG, and DSC. The derived materials demonstrated excellent inhibitory effect against P. aeruginosa and K. pneumoniae species (rating 100% inhibition) and could also inhibit Escherichia coli growth. The best antimicrobial activity observed for the derivatives suggests that chicha gum hydrophobization due to the addition of phthalic groups improved the interaction of these derivatives with bacterial cell wall components. On the other hand, the derivatives increased CC50 in macrophages but did not present acute toxicity or hemolytic activity, indicating that they are promising for use in prophylaxis or treatment of infections caused by Gram-negative bacteria.
KW - Antimicrobial activity
KW - Chemical modification
KW - Gram-negative
KW - Sterculia striata gum
UR - http://www.scopus.com/inward/record.url?scp=85090880253&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2020.117077
DO - 10.1016/j.carbpol.2020.117077
M3 - Article
C2 - 33142620
AN - SCOPUS:85090880253
SN - 0144-8617
VL - 251
SP - 1
EP - 11
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 117077
ER -
