Physicochemical and biological assessment of PEEK composites embedding natural amorphous silica fibers for biomedical applications

Patrícia R. Monich; Fernanda V. Berti; Luismar M. Porto; Bruno Henriques; Antonio P. Novaes de Oliveira; Márcio C. Fredel; Júlio C.M. Souza

doi:10.1016/j.msec.2017.05.031

Physicochemical and biological assessment of PEEK composites embedding natural amorphous silica fibers for biomedical applications

Patrícia R. Monich, Fernanda V. Berti, Luismar M. Porto, Bruno Henriques, Antonio P. Novaes de Oliveira, Márcio C. Fredel, Júlio C.M. Souza^*

^*Corresponding author for this work

Center for Interdisciplinary Research in Health (CIIS)

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

The main aim of this study was to assess the physicochemical and biological properties of a novel poly(ether ether ketone) (PEEK) composite containing 30%wt natural amorphous silica fibers (NASF). PEEK and NASF powders were previously functionalized by atomization and citric acid in order to enhance adhesion between polymeric matrix and fillers. Then, composites were produced by cold compression molding technique at 350 °C for 3 h. Materials were characterized by chemical, microstructural, thermophysical, mechanical and cytotoxic analysis. The results of the mechanical assays showed that the incorporation fibers increased the elastic modulus of the resultant PEEK composite in 56% while its microhardness increased in 26.7%. Chemical and microscopic analyses detected a good interfacial adhesion between PEEK and NASF. The results of the cytotoxicity assays indicated that PEEK/NASF composites stimulated the metabolic activity of fibroblasts and therefore a high cytocompatibility was noticed. PEEK composites embedding natural amorphous silica fibers revealed a high potential to be used in medicine and dentistry replacing several polymeric and composite materials.

Original language	English
Pages (from-to)	354-362
Number of pages	9
Journal	Materials Science and Engineering C
Volume	79
DOIs	https://doi.org/10.1016/j.msec.2017.05.031
Publication status	Published - 1 Oct 2017

Keywords

Biomaterials
Cytotoxicity
Natural amorphous silica fibers
Peek

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10.1016/j.msec.2017.05.031

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title = "Physicochemical and biological assessment of PEEK composites embedding natural amorphous silica fibers for biomedical applications",

abstract = "The main aim of this study was to assess the physicochemical and biological properties of a novel poly(ether ether ketone) (PEEK) composite containing 30%wt natural amorphous silica fibers (NASF). PEEK and NASF powders were previously functionalized by atomization and citric acid in order to enhance adhesion between polymeric matrix and fillers. Then, composites were produced by cold compression molding technique at 350 °C for 3 h. Materials were characterized by chemical, microstructural, thermophysical, mechanical and cytotoxic analysis. The results of the mechanical assays showed that the incorporation fibers increased the elastic modulus of the resultant PEEK composite in 56% while its microhardness increased in 26.7%. Chemical and microscopic analyses detected a good interfacial adhesion between PEEK and NASF. The results of the cytotoxicity assays indicated that PEEK/NASF composites stimulated the metabolic activity of fibroblasts and therefore a high cytocompatibility was noticed. PEEK composites embedding natural amorphous silica fibers revealed a high potential to be used in medicine and dentistry replacing several polymeric and composite materials.",

keywords = "Biomaterials, Cytotoxicity, Natural amorphous silica fibers, Peek",

author = "Monich, {Patr{\'i}cia R.} and Berti, {Fernanda V.} and Porto, {Luismar M.} and Bruno Henriques and {Novaes de Oliveira}, {Antonio P.} and Fredel, {M{\'a}rcio C.} and Souza, {J{\'u}lio C.M.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = oct,

day = "1",

doi = "10.1016/j.msec.2017.05.031",

language = "English",

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AU - Monich, Patrícia R.

AU - Berti, Fernanda V.

AU - Porto, Luismar M.

AU - Henriques, Bruno

AU - Novaes de Oliveira, Antonio P.

AU - Fredel, Márcio C.

AU - Souza, Júlio C.M.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - The main aim of this study was to assess the physicochemical and biological properties of a novel poly(ether ether ketone) (PEEK) composite containing 30%wt natural amorphous silica fibers (NASF). PEEK and NASF powders were previously functionalized by atomization and citric acid in order to enhance adhesion between polymeric matrix and fillers. Then, composites were produced by cold compression molding technique at 350 °C for 3 h. Materials were characterized by chemical, microstructural, thermophysical, mechanical and cytotoxic analysis. The results of the mechanical assays showed that the incorporation fibers increased the elastic modulus of the resultant PEEK composite in 56% while its microhardness increased in 26.7%. Chemical and microscopic analyses detected a good interfacial adhesion between PEEK and NASF. The results of the cytotoxicity assays indicated that PEEK/NASF composites stimulated the metabolic activity of fibroblasts and therefore a high cytocompatibility was noticed. PEEK composites embedding natural amorphous silica fibers revealed a high potential to be used in medicine and dentistry replacing several polymeric and composite materials.

AB - The main aim of this study was to assess the physicochemical and biological properties of a novel poly(ether ether ketone) (PEEK) composite containing 30%wt natural amorphous silica fibers (NASF). PEEK and NASF powders were previously functionalized by atomization and citric acid in order to enhance adhesion between polymeric matrix and fillers. Then, composites were produced by cold compression molding technique at 350 °C for 3 h. Materials were characterized by chemical, microstructural, thermophysical, mechanical and cytotoxic analysis. The results of the mechanical assays showed that the incorporation fibers increased the elastic modulus of the resultant PEEK composite in 56% while its microhardness increased in 26.7%. Chemical and microscopic analyses detected a good interfacial adhesion between PEEK and NASF. The results of the cytotoxicity assays indicated that PEEK/NASF composites stimulated the metabolic activity of fibroblasts and therefore a high cytocompatibility was noticed. PEEK composites embedding natural amorphous silica fibers revealed a high potential to be used in medicine and dentistry replacing several polymeric and composite materials.

KW - Biomaterials

KW - Cytotoxicity

KW - Natural amorphous silica fibers

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AN - SCOPUS:85019189725

SN - 0928-4931

VL - 79

SP - 354

EP - 362

JO - Materials Science and Engineering C

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ER -

Physicochemical and biological assessment of PEEK composites embedding natural amorphous silica fibers for biomedical applications

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Keywords

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