Plant extracts and SARS-CoV-2: research and applications

Sandrina A. Heleno; Marcio Carocho; Filipa S. Reis; Tânia C. S. P. Pires; Manuela Pintado; Isabel C. F. R. Ferreira; Lillian Barros

doi:10.3390/life13020386

Plant extracts and SARS-CoV-2: research and applications

Sandrina A. Heleno
, Marcio Carocho^*
, Filipa S. Reis
, Tânia C. S. P. Pires
, Manuela Pintado
, Isabel C. F. R. Ferreira
, Lillian Barros^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

64 Downloads

Abstract

The recent pandemic of COVID-19 caused by the SARS-CoV-2 virus has brought upon the world an unprecedented challenge. During its acute dissemination, a rush for vaccines started, making the scientific community come together and contribute to the development of efficient therapeutic agents and vaccines. Natural products have been used as sources of individual molecules and extracts capable of inhibiting/neutralizing several microorganisms, including viruses. Natural extracts have shown effective results against the coronavirus family, when first tested in the outbreak of SARS-CoV-1, back in 2002. In this review, the relationship between natural extracts and SARS-CoV is discussed, while also providing insight into misinformation regarding the use of plants as possible therapeutic agents. Studies with plant extracts on coronaviruses are presented, as well as the main inhibition assays and trends for the future regarding the yet unknown long-lasting effects post-infection with SARS-CoV-2.

Original language	English
Article number	386
Number of pages	21
Journal	Life
Volume	13
Issue number	2
DOIs	https://doi.org/10.3390/life13020386
Publication status	Published - 31 Jan 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-viral agents
COVID-19
Pandemic
SARS-CoV-2
Secondary metabolism

Access to Document

10.3390/life13020386Licence: CC BY

65225769Final published version, 3.35 MBLicence: CC BY

http://hdl.handle.net/10400.14/40595Licence: CC BY

Cite this

@article{be6299c9af224e689d0e9657921c4aeb,

title = "Plant extracts and SARS-CoV-2: research and applications",

abstract = "The recent pandemic of COVID-19 caused by the SARS-CoV-2 virus has brought upon the world an unprecedented challenge. During its acute dissemination, a rush for vaccines started, making the scientific community come together and contribute to the development of efficient therapeutic agents and vaccines. Natural products have been used as sources of individual molecules and extracts capable of inhibiting/neutralizing several microorganisms, including viruses. Natural extracts have shown effective results against the coronavirus family, when first tested in the outbreak of SARS-CoV-1, back in 2002. In this review, the relationship between natural extracts and SARS-CoV is discussed, while also providing insight into misinformation regarding the use of plants as possible therapeutic agents. Studies with plant extracts on coronaviruses are presented, as well as the main inhibition assays and trends for the future regarding the yet unknown long-lasting effects post-infection with SARS-CoV-2.",

keywords = "Anti-viral agents, COVID-19, Pandemic, SARS-CoV-2, Secondary metabolism",

author = "Heleno, \{Sandrina A.\} and Marcio Carocho and Reis, \{Filipa S.\} and Pires, \{T{\^a}nia C. S. P.\} and Manuela Pintado and Ferreira, \{Isabel C. F. R.\} and Lillian Barros",

note = "Funding Information: This research was funded by the Portuguese Funda{\c c}{\~a}o para Ci{\^e}ncia e Tecnologia (FCT), which financed the Centro de Investiga{\c c}{\~a}o de Montanha through (UIDB/00690/2020), as well as the researchers S. Heleno and M. Carocho (CEECIND/00831/2018, CEECIND/03040/2017) as well as L. Barros. The research was also funded by the Programa Operacional Regional Norte 2020, within the “PlantCovid” project, NORTE-01-02B7-FEDER-054870. Funding Information: The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to the CIMO (UIDB/00690/2020). Acknowledgments to the European Fund for Regional Development through the Programa Operacional Regional Norte 2020, within the “PlantCovid” project, NORTE-01-02B7-FEDER-054870. S. Heleno and M. Carocho thank FCT for their individual employment program-contract (CEECIND/00831/2018, CEECIND/03040/2017). L. Barros also thanks the national funding by FCT, through the institutional scientific employment program-contract for her contract. Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = jan,

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doi = "10.3390/life13020386",

language = "English",

volume = "13",

journal = "Life",

issn = "2075-1729",

publisher = "MDPI",

number = "2",

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T2 - research and applications

AU - Heleno, Sandrina A.

AU - Carocho, Marcio

AU - Reis, Filipa S.

AU - Pires, Tânia C. S. P.

AU - Pintado, Manuela

AU - Ferreira, Isabel C. F. R.

AU - Barros, Lillian

N1 - Funding Information: This research was funded by the Portuguese Fundação para Ciência e Tecnologia (FCT), which financed the Centro de Investigação de Montanha through (UIDB/00690/2020), as well as the researchers S. Heleno and M. Carocho (CEECIND/00831/2018, CEECIND/03040/2017) as well as L. Barros. The research was also funded by the Programa Operacional Regional Norte 2020, within the “PlantCovid” project, NORTE-01-02B7-FEDER-054870. Funding Information: The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to the CIMO (UIDB/00690/2020). Acknowledgments to the European Fund for Regional Development through the Programa Operacional Regional Norte 2020, within the “PlantCovid” project, NORTE-01-02B7-FEDER-054870. S. Heleno and M. Carocho thank FCT for their individual employment program-contract (CEECIND/00831/2018, CEECIND/03040/2017). L. Barros also thanks the national funding by FCT, through the institutional scientific employment program-contract for her contract. Publisher Copyright: © 2023 by the authors.

PY - 2023/1/31

Y1 - 2023/1/31

N2 - The recent pandemic of COVID-19 caused by the SARS-CoV-2 virus has brought upon the world an unprecedented challenge. During its acute dissemination, a rush for vaccines started, making the scientific community come together and contribute to the development of efficient therapeutic agents and vaccines. Natural products have been used as sources of individual molecules and extracts capable of inhibiting/neutralizing several microorganisms, including viruses. Natural extracts have shown effective results against the coronavirus family, when first tested in the outbreak of SARS-CoV-1, back in 2002. In this review, the relationship between natural extracts and SARS-CoV is discussed, while also providing insight into misinformation regarding the use of plants as possible therapeutic agents. Studies with plant extracts on coronaviruses are presented, as well as the main inhibition assays and trends for the future regarding the yet unknown long-lasting effects post-infection with SARS-CoV-2.

AB - The recent pandemic of COVID-19 caused by the SARS-CoV-2 virus has brought upon the world an unprecedented challenge. During its acute dissemination, a rush for vaccines started, making the scientific community come together and contribute to the development of efficient therapeutic agents and vaccines. Natural products have been used as sources of individual molecules and extracts capable of inhibiting/neutralizing several microorganisms, including viruses. Natural extracts have shown effective results against the coronavirus family, when first tested in the outbreak of SARS-CoV-1, back in 2002. In this review, the relationship between natural extracts and SARS-CoV is discussed, while also providing insight into misinformation regarding the use of plants as possible therapeutic agents. Studies with plant extracts on coronaviruses are presented, as well as the main inhibition assays and trends for the future regarding the yet unknown long-lasting effects post-infection with SARS-CoV-2.

KW - Anti-viral agents

KW - COVID-19

KW - Pandemic

KW - SARS-CoV-2

KW - Secondary metabolism

UR - https://www.scopus.com/pages/publications/85149238214

U2 - 10.3390/life13020386

DO - 10.3390/life13020386

M3 - Review article

C2 - 36836744

AN - SCOPUS:85149238214

SN - 2075-1729

VL - 13

JO - Life

JF - Life

IS - 2

M1 - 386

ER -

Plant extracts and SARS-CoV-2: research and applications

Abstract

UN SDGs

Keywords

Access to Document

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PLANTCOVID: Aplicações de extratos de plantas com ação dirigida ao SARS-CoV-2

Cite this

Plant extracts and SARS-CoV-2: research and applications

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Projects

PLANTCOVID: Aplicações de extratos de plantas com ação dirigida ao SARS-CoV-2

Cite this