Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications

P. Coimbra*, P. Ferreira, H. C. de Sousa, P. Batista, M. A. Rodrigues, I. J. Correia, M. H. Gil

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

138 Citations (Scopus)

Abstract

In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic.

Original languageEnglish
Pages (from-to)112-118
Number of pages7
JournalInternational Journal of Biological Macromolecules
Volume48
Issue number1
DOIs
Publication statusPublished - 1 Jan 2011
Externally publishedYes

Keywords

  • Cytotoxicity
  • Osteoblasts
  • Polyelectrolyte complexes
  • Polymeric scaffold

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