TY - JOUR
T1 - Prevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly
AU - Araujo-Castro, Marta
AU - García-Centeno, Rogelio
AU - González, Laura
AU - Nobre, Ema Lacerda
AU - Severino, Mariana de Griné
AU - Goi, Jessica
AU - Pena, Marta María Pérez
AU - Torre, Edelmiro Menéndez
AU - Aida, Claudia Lozano
AU - Novoa-Testa, Iría
AU - Cordido, Fernando
AU - Sánchón, Raúl
AU - Guerrero-Pérez, Fernando
AU - Rodríguez, Rosario Oliva
AU - Rodríguez-Jiménez, Beatriz
AU - García, María Dolores Ollero
AU - Echarri, Ana Irigaray
AU - Simó-Servat, Andreu
AU - Rodríguez, María Dolores Moure
AU - Novo-Rodríguez, Cristina
AU - Calatayud, María
AU - Villar-Taibo, Rocío
AU - Bernabéu, Ignacio
AU - Tenorio-Jimenéz, Carmen
AU - Molero, Inmaculada González
AU - Iglesias, Pedro
AU - Blanco, Concepción
AU - Lara, Fernando Vidal-Ostos de
AU - Aulinas, Anna
AU - Roca, Queralt Asla
AU - Fano, Miguel Paja
AU - Martínez, Antonio Rivera
AU - Cardoso, Luís Miguel
AU - Marques, Pedro
AU - Giustina, Andrea
AU - Marazuela, Mónica
AU - Puig-Domingo, Manel
AU - Biagetti, Betina
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
PY - 2025/10/25
Y1 - 2025/10/25
N2 - Purpose: To analyze the prevalence of hypertension in patients with acromegaly and assess the impact of acromegaly treatment on blood pressure (BP) outcomes. Methods: Retrospective multicenter study of 434 patients with acromegaly surveilled at 25 tertiary hospitals in Spain and Portugal. The cohort was divided into two subgroups: patients with (n = 209) and without (n = 225) hypertension at the time of acromegaly diagnosis. Results: Of the 434 patients, 209 (48.2%) had hypertension at the time of acromegaly diagnosis. Patients with acromegaly and hypertension were older and had a higher prevalence of cardiovascular disease and risk factors. A significant BP improvement was observed 3 months after pituitary surgery, with a marked reduction of the SBP (ΔSBP − 5.0mmHg, 95%CI -2.37 to -7.61) and DBP (ΔDBP − 2.2mmHg, 95% CI -0.66 to -3.75). Over a median follow-up of 8.4 years [IQR 4.8–12.8], 16% (n = 35/218) of initially normotensive patients developed hypertension, while 14.1% (n = 27/192) of hypertensive patients achieved hypertension remission. Hypertension remission was more likely in patients taking fewer antihypertensive drugs and with higher IGF1 levels at diagnosis, and in those who had a greater decrease in GH and IGF-1 after surgery. Conclusion: At the time of acromegaly diagnosis up to 50% of patients have hypertension, and around 15% of them experience hypertension remission after pituitary surgery. The probability of remission is higher in patients with milder baseline hypertension and higher IGF-1 levels and in those achieving a greater postoperative decrease of GH and IGF-1.
AB - Purpose: To analyze the prevalence of hypertension in patients with acromegaly and assess the impact of acromegaly treatment on blood pressure (BP) outcomes. Methods: Retrospective multicenter study of 434 patients with acromegaly surveilled at 25 tertiary hospitals in Spain and Portugal. The cohort was divided into two subgroups: patients with (n = 209) and without (n = 225) hypertension at the time of acromegaly diagnosis. Results: Of the 434 patients, 209 (48.2%) had hypertension at the time of acromegaly diagnosis. Patients with acromegaly and hypertension were older and had a higher prevalence of cardiovascular disease and risk factors. A significant BP improvement was observed 3 months after pituitary surgery, with a marked reduction of the SBP (ΔSBP − 5.0mmHg, 95%CI -2.37 to -7.61) and DBP (ΔDBP − 2.2mmHg, 95% CI -0.66 to -3.75). Over a median follow-up of 8.4 years [IQR 4.8–12.8], 16% (n = 35/218) of initially normotensive patients developed hypertension, while 14.1% (n = 27/192) of hypertensive patients achieved hypertension remission. Hypertension remission was more likely in patients taking fewer antihypertensive drugs and with higher IGF1 levels at diagnosis, and in those who had a greater decrease in GH and IGF-1 after surgery. Conclusion: At the time of acromegaly diagnosis up to 50% of patients have hypertension, and around 15% of them experience hypertension remission after pituitary surgery. The probability of remission is higher in patients with milder baseline hypertension and higher IGF-1 levels and in those achieving a greater postoperative decrease of GH and IGF-1.
KW - Acromegaly
KW - Blood pressure
KW - Growth hormone
KW - Hypertension
KW - IGF-1
UR - https://www.scopus.com/pages/publications/105019705259
U2 - 10.1007/s11102-025-01586-1
DO - 10.1007/s11102-025-01586-1
M3 - Article
C2 - 41139153
AN - SCOPUS:105019705259
SN - 1386-341X
VL - 28
JO - Pituitary
JF - Pituitary
IS - 6
M1 - 119
ER -