TY - JOUR
T1 - Prevalence of viral hepatitis B and C in riverside communities of the Tucuruí Dam, Pará, Brazil
AU - de Almeida, Marcella Kelly Costa
AU - dos Santos, Kemper Nunes
AU - Fecury, Amanda Alves
AU - de Oliveira, Cláudia Suellen Ferro
AU - Freitas, Andrei Silva
AU - Quaresma, Juarez Antonio Simões
AU - Fuzii, Hellen Thais
AU - Martins, Luisa Caricio
PY - 2012/12
Y1 - 2012/12
N2 - Epidemiologically, the relevance of infection caused by hepatitis viruses is related mainly to their wide geographic distribution and the large number of infected individuals in all parts of the world. In this study, 668 residents from the islands around the Tucuruí Dam were selected. Blood samples were collected for investigation of serological markers (HBsAg, total anti-HBc, anti-HBS, and anti-HCV) by enzyme immunoassays. HCV-positive subjects were tested using RT-PCR and RFLP for the identification of viral genotypes. Among the 668 subjects studied, 1.9% were HBsAg positive, 28% were total anti-HBc positive, and 41.9% were anti-HBs positive. The anti-HBs marker alone (vaccine response) was detected in 25.7% of the volunteers. Anti-HCV antibody was detected in 2.2% of the subjects and genotype 1 was the predominant genotype (70%). The results indicate an intermediate level of HBV and HCV endemicity in the region studied, as well as low HBV vaccination coverage.
AB - Epidemiologically, the relevance of infection caused by hepatitis viruses is related mainly to their wide geographic distribution and the large number of infected individuals in all parts of the world. In this study, 668 residents from the islands around the Tucuruí Dam were selected. Blood samples were collected for investigation of serological markers (HBsAg, total anti-HBc, anti-HBS, and anti-HCV) by enzyme immunoassays. HCV-positive subjects were tested using RT-PCR and RFLP for the identification of viral genotypes. Among the 668 subjects studied, 1.9% were HBsAg positive, 28% were total anti-HBc positive, and 41.9% were anti-HBs positive. The anti-HBs marker alone (vaccine response) was detected in 25.7% of the volunteers. Anti-HCV antibody was detected in 2.2% of the subjects and genotype 1 was the predominant genotype (70%). The results indicate an intermediate level of HBV and HCV endemicity in the region studied, as well as low HBV vaccination coverage.
KW - HBV
KW - HCV
KW - Molecular biology
KW - Riverside communities
UR - http://www.scopus.com/inward/record.url?scp=84867718668&partnerID=8YFLogxK
U2 - 10.1002/jmv.23356
DO - 10.1002/jmv.23356
M3 - Article
C2 - 23080495
AN - SCOPUS:84867718668
SN - 0146-6615
VL - 84
SP - 1907
EP - 1912
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 12
ER -
