Prevention and treatment of diabetic retinopathy by natural antioxidant containing in chitosan-based nanomedicines

S. B. da Silva, D. Carvalho, M. Pintado, B. Sarmento

Research output: Contribution to conferenceAbstractpeer-review



Oxidative processes are critical factors in ocular conditions that may lead to pathologies such as Diabetic Retinopahty due to structural and functional modification of the tissues, apoptosis of capillary cells and retinal microvascular changes, making the loss of vision inevitable. Application of antioxidants may reduce apoptosis and restores partially functional tissues. Considering the multiple benefits of antioxidants in DR and that conjunctival drug permeability improvement is one of the major challenges in ocular drug delivery, the major topic of this work is to study the absorption capacity and consequent bioavailability of natural antioxidants incorporated in chitosan-based nanoparticles to prevent and treat DR. In this regards, it is proposed to characterize, quantify and compare the antioxidant potential of Salvia sp. and Satureja montana extracts and their main pure antioxidants: rutin, caffeic and clorogenic acid. Then, antioxidant compounds are encapsulated into different chitosan-based nanoparticles, nanoparticles and release profile characterized and ocular permeation evaluated using in vitro cell models. Finally, the effect of antioxidant nanomedicines across human ocular is evaluated in diabetic animal after topical administration in vivo.
Original languageEnglish
Number of pages1
Publication statusPublished - Mar 2010
Event1ª Workshop anual BioPlant - Porto, Portugal
Duration: 29 Mar 201030 Mar 2010


Workshop1ª Workshop anual BioPlant


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