Protective effects of Lavandula viridis L'Hér extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line

Patrícia Costa; Bruno Sarmento; Sandra Gonçalves; Anabela Romano

doi:10.1016/j.indcrop.2013.07.054

Protective effects of Lavandula viridis L'Hér extracts and rosmarinic acid against H₂O₂-induced oxidative damage in A172 human astrocyte cell line

Patrícia Costa, Bruno Sarmento, Sandra Gonçalves, Anabela Romano^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

We investigated the neuroprotective effect of Lavandula viridis extracts (infusion, water:ethanol and methanol) and rosmarinic acid, the major compound present in the extracts, against oxidative damage induced by hydrogen peroxide (H₂O₂) in A172 human astrocyte cell line regarding the neurotoxic effect, intracellular reactive oxygen species (ROS) production and the activity of the antioxidant enzyme catalase (CAT). We found that L. viridis extracts and rosmarinic acid protected A172 astrocytes against H₂O₂ and reduced intracellular ROS accumulation. Furthermore, the protection effect was not caused by modulation of CAT suggesting that other intracellular mechanisms are involved in the neuroprotective effect. Our results highlight that L. viridis extracts and rosmarinic acid have beneficial effects against oxidative damage associated with neurodegenerative diseases.

Original language	English
Pages (from-to)	361-365
Number of pages	5
Journal	Industrial Crops and Products
Volume	50
DOIs	https://doi.org/10.1016/j.indcrop.2013.07.054
Publication status	Published - Oct 2013

Keywords

Hydrogen peroxide
Lavandula viridis
Neuroprotective effect
Phenolic compounds
Reactive oxygen species
Rosmarinic acid

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10.1016/j.indcrop.2013.07.054

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title = "Protective effects of Lavandula viridis L'H{\'e}r extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line",

abstract = "We investigated the neuroprotective effect of Lavandula viridis extracts (infusion, water:ethanol and methanol) and rosmarinic acid, the major compound present in the extracts, against oxidative damage induced by hydrogen peroxide (H2O2) in A172 human astrocyte cell line regarding the neurotoxic effect, intracellular reactive oxygen species (ROS) production and the activity of the antioxidant enzyme catalase (CAT). We found that L. viridis extracts and rosmarinic acid protected A172 astrocytes against H2O2 and reduced intracellular ROS accumulation. Furthermore, the protection effect was not caused by modulation of CAT suggesting that other intracellular mechanisms are involved in the neuroprotective effect. Our results highlight that L. viridis extracts and rosmarinic acid have beneficial effects against oxidative damage associated with neurodegenerative diseases.",

keywords = "Hydrogen peroxide, Lavandula viridis, Neuroprotective effect, Phenolic compounds, Reactive oxygen species, Rosmarinic acid",

author = "Patr{\'i}cia Costa and Bruno Sarmento and Sandra Gon{\c c}alves and Anabela Romano",

note = "Funding Information: P. Costa and S. Gon{\c c}alves acknowledge grants from the Portuguese Science and Technology Foundation (FCT) ( SFRH/BD/63505/2009 and SFRH/BPD/31534/2006 , respectively).",

year = "2013",

month = oct,

doi = "10.1016/j.indcrop.2013.07.054",

language = "English",

volume = "50",

pages = "361--365",

journal = "Industrial Crops and Products",

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T1 - Protective effects of Lavandula viridis L'Hér extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line

AU - Costa, Patrícia

AU - Sarmento, Bruno

AU - Gonçalves, Sandra

AU - Romano, Anabela

N1 - Funding Information: P. Costa and S. Gonçalves acknowledge grants from the Portuguese Science and Technology Foundation (FCT) ( SFRH/BD/63505/2009 and SFRH/BPD/31534/2006 , respectively).

PY - 2013/10

Y1 - 2013/10

N2 - We investigated the neuroprotective effect of Lavandula viridis extracts (infusion, water:ethanol and methanol) and rosmarinic acid, the major compound present in the extracts, against oxidative damage induced by hydrogen peroxide (H2O2) in A172 human astrocyte cell line regarding the neurotoxic effect, intracellular reactive oxygen species (ROS) production and the activity of the antioxidant enzyme catalase (CAT). We found that L. viridis extracts and rosmarinic acid protected A172 astrocytes against H2O2 and reduced intracellular ROS accumulation. Furthermore, the protection effect was not caused by modulation of CAT suggesting that other intracellular mechanisms are involved in the neuroprotective effect. Our results highlight that L. viridis extracts and rosmarinic acid have beneficial effects against oxidative damage associated with neurodegenerative diseases.

AB - We investigated the neuroprotective effect of Lavandula viridis extracts (infusion, water:ethanol and methanol) and rosmarinic acid, the major compound present in the extracts, against oxidative damage induced by hydrogen peroxide (H2O2) in A172 human astrocyte cell line regarding the neurotoxic effect, intracellular reactive oxygen species (ROS) production and the activity of the antioxidant enzyme catalase (CAT). We found that L. viridis extracts and rosmarinic acid protected A172 astrocytes against H2O2 and reduced intracellular ROS accumulation. Furthermore, the protection effect was not caused by modulation of CAT suggesting that other intracellular mechanisms are involved in the neuroprotective effect. Our results highlight that L. viridis extracts and rosmarinic acid have beneficial effects against oxidative damage associated with neurodegenerative diseases.

KW - Hydrogen peroxide

KW - Lavandula viridis

KW - Neuroprotective effect

KW - Phenolic compounds

KW - Reactive oxygen species

KW - Rosmarinic acid

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DO - 10.1016/j.indcrop.2013.07.054

M3 - Article

AN - SCOPUS:84883032293

SN - 0926-6690

VL - 50

SP - 361

EP - 365

JO - Industrial Crops and Products

JF - Industrial Crops and Products

ER -

Protective effects of Lavandula viridis L'Hér extracts and rosmarinic acid against H₂O₂-induced oxidative damage in A172 human astrocyte cell line

Abstract

Keywords

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