Protective effects of Lavandula viridis L'Hér extracts and rosmarinic acid against H2O2-induced oxidative damage in A172 human astrocyte cell line

Patrícia Costa, Bruno Sarmento, Sandra Gonçalves, Anabela Romano*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

We investigated the neuroprotective effect of Lavandula viridis extracts (infusion, water:ethanol and methanol) and rosmarinic acid, the major compound present in the extracts, against oxidative damage induced by hydrogen peroxide (H2O2) in A172 human astrocyte cell line regarding the neurotoxic effect, intracellular reactive oxygen species (ROS) production and the activity of the antioxidant enzyme catalase (CAT). We found that L. viridis extracts and rosmarinic acid protected A172 astrocytes against H2O2 and reduced intracellular ROS accumulation. Furthermore, the protection effect was not caused by modulation of CAT suggesting that other intracellular mechanisms are involved in the neuroprotective effect. Our results highlight that L. viridis extracts and rosmarinic acid have beneficial effects against oxidative damage associated with neurodegenerative diseases.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalIndustrial Crops and Products
Volume50
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Hydrogen peroxide
  • Lavandula viridis
  • Neuroprotective effect
  • Phenolic compounds
  • Reactive oxygen species
  • Rosmarinic acid

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