Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry

Ki Bum Won; Byoung Kwon Lee; Hyung Bok Park; Ran Heo; Sang Eun Lee; Asim Rizvi; Fay Y. Lin; Amit Kumar; Martin Hadamitzky; Yong Jin Kim; Ji Min Sung; Edoardo Conte; Daniele Andreini; Gianluca Pontone; Matthew J. Budoff; Ilan Gottlieb; Eun Ju Chun; Filippo Cademartiri; Erica Maffei; Hugo Marques; Pedro de Araújo Gonçalves; Jonathon A. Leipsic; Sanghoon Shin; Jung Hyun Choi; Renu Virmani; Habib Samady; Kavitha Chinnaiyan; Gilbert L. Raff; Peter H. Stone; Daniel S. Berman; Jagat Narula; Leslee J. Shaw; Jeroen J. Bax; James K. Min; Hyuk Jae Chang

doi:10.1186/s12933-020-01081-w

Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry

Ki Bum Won, Byoung Kwon Lee, Hyung Bok Park, Ran Heo, Sang Eun Lee, Asim Rizvi, Fay Y. Lin, Amit Kumar, Martin Hadamitzky, Yong Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo MarquesPedro de Araújo Gonçalves, Jonathon A. Leipsic, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Gilbert L. Raff, Peter H. Stone, Daniel S. Berman, Jagat Narula, Leslee J. Shaw, Jeroen J. Bax, James K. Min, Hyuk Jae Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Background: The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Methods: A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index > 0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year. Results: The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P < 0.001) and the annual change of total PV (group I: 5.7 (0.0-20.2), group II: 7.6 (0.5-23.5), and group III: 9.4 (1.4-27.7); P = 0.010) were different among all groups. The risk of PP (odds ratio [OR] 1.648; 95% confidence interval [CI] 1.167-2.327; P = 0.005) and rapid PP (OR 1.777; 95% CI 1.288-2.451; P < 0.001) was increased in group III compared to that in group I. TyG index had a positive and significant association with an increased risk of PP and rapid PP after adjusting for confounding factors. Conclusion: TyG index is an independent predictive marker for the progression of coronary atherosclerosis. Clinical registration ClinicalTrials.gov NCT02803411.

Original language	English
Article number	113
Number of pages	10
Journal	Cardiovascular Diabetology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12933-020-01081-w
Publication status	Published - 18 Jul 2020
Externally published	Yes

Keywords

Atherosclerosis
Coronary artery disease
Coronary computed tomography angiography
Triglyceride glucose index

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Won, K. B., Lee, B. K., Park, H. B., Heo, R., Lee, S. E., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y. J., Sung, J. M., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Chun, E. J., Cademartiri, F., Maffei, E., ... Chang, H. J. (2020). Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. Cardiovascular Diabetology, 19(1), Article 113. https://doi.org/10.1186/s12933-020-01081-w

@article{d102fb1e98bb4be3b3013a5b8623e7a4,

title = "Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry",

abstract = "Background: The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Methods: A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index > 0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year. Results: The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P < 0.001) and the annual change of total PV (group I: 5.7 (0.0-20.2), group II: 7.6 (0.5-23.5), and group III: 9.4 (1.4-27.7); P = 0.010) were different among all groups. The risk of PP (odds ratio [OR] 1.648; 95% confidence interval [CI] 1.167-2.327; P = 0.005) and rapid PP (OR 1.777; 95% CI 1.288-2.451; P < 0.001) was increased in group III compared to that in group I. TyG index had a positive and significant association with an increased risk of PP and rapid PP after adjusting for confounding factors. Conclusion: TyG index is an independent predictive marker for the progression of coronary atherosclerosis. Clinical registration ClinicalTrials.gov NCT02803411.",

keywords = "Atherosclerosis, Coronary artery disease, Coronary computed tomography angiography, Triglyceride glucose index",

author = "Won, {Ki Bum} and Lee, {Byoung Kwon} and Park, {Hyung Bok} and Ran Heo and Lee, {Sang Eun} and Asim Rizvi and Lin, {Fay Y.} and Amit Kumar and Martin Hadamitzky and Kim, {Yong Jin} and Sung, {Ji Min} and Edoardo Conte and Daniele Andreini and Gianluca Pontone and Budoff, {Matthew J.} and Ilan Gottlieb and Chun, {Eun Ju} and Filippo Cademartiri and Erica Maffei and Hugo Marques and Gon{\c c}alves, {Pedro de Ara{\'u}jo} and Leipsic, {Jonathon A.} and Sanghoon Shin and Choi, {Jung Hyun} and Renu Virmani and Habib Samady and Kavitha Chinnaiyan and Raff, {Gilbert L.} and Stone, {Peter H.} and Berman, {Daniel S.} and Jagat Narula and Shaw, {Leslee J.} and Bax, {Jeroen J.} and Min, {James K.} and Chang, {Hyuk Jae}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s).",

year = "2020",

month = jul,

day = "18",

doi = "10.1186/s12933-020-01081-w",

language = "English",

volume = "19",

journal = "Cardiovascular Diabetology",

issn = "1475-2840",

publisher = "BioMed Central Ltd.",

number = "1",

}

Won, KB, Lee, BK, Park, HB, Heo, R, Lee, SE, Rizvi, A, Lin, FY, Kumar, A, Hadamitzky, M, Kim, YJ, Sung, JM, Conte, E, Andreini, D, Pontone, G, Budoff, MJ, Gottlieb, I, Chun, EJ, Cademartiri, F, Maffei, E, Marques, H, Gonçalves, PDA, Leipsic, JA, Shin, S, Choi, JH, Virmani, R, Samady, H, Chinnaiyan, K, Raff, GL, Stone, PH, Berman, DS, Narula, J, Shaw, LJ, Bax, JJ, Min, JK & Chang, HJ 2020, 'Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry', Cardiovascular Diabetology, vol. 19, no. 1, 113. https://doi.org/10.1186/s12933-020-01081-w

Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. / Won, Ki Bum; Lee, Byoung Kwon; Park, Hyung Bok et al.
In: Cardiovascular Diabetology, Vol. 19, No. 1, 113, 18.07.2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Quantitative assessment of coronary plaque volume change related to triglyceride glucose index

T2 - the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry

AU - Won, Ki Bum

AU - Lee, Byoung Kwon

AU - Park, Hyung Bok

AU - Heo, Ran

AU - Lee, Sang Eun

AU - Rizvi, Asim

AU - Lin, Fay Y.

AU - Kumar, Amit

AU - Hadamitzky, Martin

AU - Kim, Yong Jin

AU - Sung, Ji Min

AU - Conte, Edoardo

AU - Andreini, Daniele

AU - Pontone, Gianluca

AU - Budoff, Matthew J.

AU - Gottlieb, Ilan

AU - Chun, Eun Ju

AU - Cademartiri, Filippo

AU - Maffei, Erica

AU - Marques, Hugo

AU - Gonçalves, Pedro de Araújo

AU - Leipsic, Jonathon A.

AU - Shin, Sanghoon

AU - Choi, Jung Hyun

AU - Virmani, Renu

AU - Samady, Habib

AU - Chinnaiyan, Kavitha

AU - Raff, Gilbert L.

AU - Stone, Peter H.

AU - Berman, Daniel S.

AU - Narula, Jagat

AU - Shaw, Leslee J.

AU - Bax, Jeroen J.

AU - Min, James K.

AU - Chang, Hyuk Jae

PY - 2020/7/18

Y1 - 2020/7/18

N2 - Background: The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Methods: A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index > 0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year. Results: The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P < 0.001) and the annual change of total PV (group I: 5.7 (0.0-20.2), group II: 7.6 (0.5-23.5), and group III: 9.4 (1.4-27.7); P = 0.010) were different among all groups. The risk of PP (odds ratio [OR] 1.648; 95% confidence interval [CI] 1.167-2.327; P = 0.005) and rapid PP (OR 1.777; 95% CI 1.288-2.451; P < 0.001) was increased in group III compared to that in group I. TyG index had a positive and significant association with an increased risk of PP and rapid PP after adjusting for confounding factors. Conclusion: TyG index is an independent predictive marker for the progression of coronary atherosclerosis. Clinical registration ClinicalTrials.gov NCT02803411.

AB - Background: The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Methods: A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index > 0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) ≥ 1.0%/year. Results: The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P < 0.001) and the annual change of total PV (group I: 5.7 (0.0-20.2), group II: 7.6 (0.5-23.5), and group III: 9.4 (1.4-27.7); P = 0.010) were different among all groups. The risk of PP (odds ratio [OR] 1.648; 95% confidence interval [CI] 1.167-2.327; P = 0.005) and rapid PP (OR 1.777; 95% CI 1.288-2.451; P < 0.001) was increased in group III compared to that in group I. TyG index had a positive and significant association with an increased risk of PP and rapid PP after adjusting for confounding factors. Conclusion: TyG index is an independent predictive marker for the progression of coronary atherosclerosis. Clinical registration ClinicalTrials.gov NCT02803411.

KW - Atherosclerosis

KW - Coronary artery disease

KW - Coronary computed tomography angiography

KW - Triglyceride glucose index

UR - http://www.scopus.com/inward/record.url?scp=85088214952&partnerID=8YFLogxK

U2 - 10.1186/s12933-020-01081-w

DO - 10.1186/s12933-020-01081-w

M3 - Article

C2 - 32682451

AN - SCOPUS:85088214952

SN - 1475-2840

VL - 19

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

IS - 1

M1 - 113

ER -

Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry

Abstract

Keywords

UN SDGs

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