TY - JOUR
T1 - Recent advances in cancer vaccines
T2 - challenges, achievements, and futuristic prospects
AU - Gupta, Madhu
AU - Wahi, Abhishek
AU - Sharma, Priyanka
AU - Nagpal, Riya
AU - Raina, Neha
AU - Kaurav, Monika
AU - Bhattacharya, Jaydeep
AU - Oliveira, Sonia M. Rodrigues
AU - Dolma, Karma G.
AU - Paul, Alok K.
AU - Pereira, Maria de Lourdes
AU - Wilairatana, Polrat
AU - Rahmatullah, Mohammed
AU - Nissapatorn, Veeranoot
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/12
Y1 - 2022/12
N2 - Cancer is a chronic disease, and it can be lethal due to limited therapeutic options. The conventional treatment options for cancer have numerous challenges, such as a low blood circulation time as well as poor solubility of anticancer drugs. Therapeutic cancer vaccines emerged to try to improve anticancer drugs’ efficiency and to deliver them to the target site. Cancer vaccines are considered a viable therapeutic technique for most solid tumors. Vaccines boost antitumor immunity by delivering tumor antigens, nucleic acids, entire cells, and peptides. Cancer vaccines are designed to induce long-term antitumor memory, causing tumor regression, eradicate minimal residual illness, and prevent non-specific or unpleasant effects. These vaccines can assist in the elimination of cancer cells from various organs or organ systems in the body, with minimal risk of tumor recurrence or metastasis. Vaccines and antigens for anticancer therapy are discussed in this review, including current vaccine adjuvants and mechanisms of action for various types of vaccines, such as DNA- or mRNA-based cancer vaccines. Potential applications of these vaccines focusing on their clinical use for better therapeutic efficacy are also discussed along with the latest research available in this field.
AB - Cancer is a chronic disease, and it can be lethal due to limited therapeutic options. The conventional treatment options for cancer have numerous challenges, such as a low blood circulation time as well as poor solubility of anticancer drugs. Therapeutic cancer vaccines emerged to try to improve anticancer drugs’ efficiency and to deliver them to the target site. Cancer vaccines are considered a viable therapeutic technique for most solid tumors. Vaccines boost antitumor immunity by delivering tumor antigens, nucleic acids, entire cells, and peptides. Cancer vaccines are designed to induce long-term antitumor memory, causing tumor regression, eradicate minimal residual illness, and prevent non-specific or unpleasant effects. These vaccines can assist in the elimination of cancer cells from various organs or organ systems in the body, with minimal risk of tumor recurrence or metastasis. Vaccines and antigens for anticancer therapy are discussed in this review, including current vaccine adjuvants and mechanisms of action for various types of vaccines, such as DNA- or mRNA-based cancer vaccines. Potential applications of these vaccines focusing on their clinical use for better therapeutic efficacy are also discussed along with the latest research available in this field.
KW - Antigen
KW - Cancer
KW - Immunotherapy
KW - Nucleic acid
KW - Peptides
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85144661069&partnerID=8YFLogxK
U2 - 10.3390/vaccines10122011
DO - 10.3390/vaccines10122011
M3 - Review article
C2 - 36560420
SN - 2076-393X
VL - 10
JO - Vaccines
JF - Vaccines
IS - 12
M1 - 2011
ER -
