Recent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptides

Patrícia Batista, Pedro M. Castro, Ana Raquel Madureira, Bruno Sarmento, Manuela Pintado*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)

Abstract

Bioactive proteins and peptides have been used with either prophylactic or therapeutic purposes, presenting inherent advantages as high specificity and biocompatibility. Nanocarriers play an important role in the stabilization of proteins and peptides, offering enhanced buccal permeation and protection while crossing the gastrointestinal tract. Moreover, preparation of nanoparticles as oral delivery systems for proteins/peptides may include tailored formulation along with functionalization aiming bioavailability enhancement of carried proteins or peptides. Oral delivery systems, namely buccal delivery systems, represent an interesting alternative route to parenteric delivery systems to carry proteins and peptides, resulting in higher comfort of administration and, therefore, compliance to treatment. This paper outlines an extensive overview of the existing publications on proteins/peptides oral nanocarriers delivery systems, with special focus on buccal route. Manufacturing aspects of most commonly used nanoparticles for oral delivery (e.g. polymeric nanoparticles using synthetic or natural polymers and lipid nanoparticles) advantages and limitations and potential applications of nanoparticles as proteins/peptides delivery systems will also be thoroughly addressed.
Original languageEnglish
Pages (from-to)112-123
Number of pages12
JournalPeptides
Volume101
DOIs
Publication statusPublished - Mar 2018

Keywords

  • Bioactive protein/peptides
  • Buccal delivery
  • Delivery systems
  • Nanoparticles
  • Oral delivery

Fingerprint

Dive into the research topics of 'Recent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptides'. Together they form a unique fingerprint.

Cite this