Results of the Seventh Scientific Workshop of ECCO: precision medicine in IBD-disease outcome and response to therapy

Bram Verstockt; Nurulamin M. Noor; Urko M. Marigorta; Polychronis Pavlidis; Parakkal Deepak; Ryan C. Ungaro; Claudio Fiocchi; Joana Torres; Michael Scharl

doi:10.1093/ecco-jcc/jjab050

Results of the Seventh Scientific Workshop of ECCO: precision medicine in IBD-disease outcome and response to therapy

Bram Verstockt^*, Nurulamin M. Noor, Urko M. Marigorta, Polychronis Pavlidis, Parakkal Deepak, Ryan C. Ungaro, Claudio Fiocchi, Joana Torres, Michael Scharl

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Inflammatory bowel diseases [IBD] are a heterogeneous spectrum with two extreme phenotypes, Crohn's disease [CD] and ulcerative colitis [UC], which both represent numerous phenotypical variations. Hence, we should no longer approach all IBD patients similarly, but rather aim to rethink clinical classifications and modify treatment algorithms to usher in a new era of precision medicine in IBD. This scientific ECCO workshop aims to provide a state-of-the-art overview on prognostic and predictive markers, shed light on key questions in biomarker development, propose best practices in IBD biomarker development [including trial design], and discuss the potential for multi-omic data integration to help drive further advances to make precision medicine a reality in IBD.

Original language	English
Pages (from-to)	1431-1442
Number of pages	12
Journal	Journal of Crohn's and Colitis
Volume	15
Issue number	9
DOIs	https://doi.org/10.1093/ecco-jcc/jjab050
Publication status	Published - 1 Sept 2021
Externally published	Yes

Keywords

Disease outcome
Disease prognosis
Inflammatory bowel diseases
Personalised medicine
Precision medicine
Response to therapy

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10.1093/ecco-jcc/jjab050

Cite this

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title = "Results of the Seventh Scientific Workshop of ECCO: precision medicine in IBD-disease outcome and response to therapy",

abstract = "Inflammatory bowel diseases [IBD] are a heterogeneous spectrum with two extreme phenotypes, Crohn's disease [CD] and ulcerative colitis [UC], which both represent numerous phenotypical variations. Hence, we should no longer approach all IBD patients similarly, but rather aim to rethink clinical classifications and modify treatment algorithms to usher in a new era of precision medicine in IBD. This scientific ECCO workshop aims to provide a state-of-the-art overview on prognostic and predictive markers, shed light on key questions in biomarker development, propose best practices in IBD biomarker development [including trial design], and discuss the potential for multi-omic data integration to help drive further advances to make precision medicine a reality in IBD.",

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AU - Marigorta, Urko M.

AU - Pavlidis, Polychronis

AU - Deepak, Parakkal

AU - Ungaro, Ryan C.

AU - Fiocchi, Claudio

AU - Torres, Joana

AU - Scharl, Michael

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AB - Inflammatory bowel diseases [IBD] are a heterogeneous spectrum with two extreme phenotypes, Crohn's disease [CD] and ulcerative colitis [UC], which both represent numerous phenotypical variations. Hence, we should no longer approach all IBD patients similarly, but rather aim to rethink clinical classifications and modify treatment algorithms to usher in a new era of precision medicine in IBD. This scientific ECCO workshop aims to provide a state-of-the-art overview on prognostic and predictive markers, shed light on key questions in biomarker development, propose best practices in IBD biomarker development [including trial design], and discuss the potential for multi-omic data integration to help drive further advances to make precision medicine a reality in IBD.

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KW - Personalised medicine

KW - Precision medicine

KW - Response to therapy

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Results of the Seventh Scientific Workshop of ECCO: precision medicine in IBD-disease outcome and response to therapy

Abstract

Keywords

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