TY - JOUR
T1 - Retrospective Spatio-Temporal Dynamics of Dengue Virus 1, 2 and 4 in Paraguay
AU - Vazquez, Cynthia
AU - Alcantara, Luiz Carlos Junior
AU - Fonseca, Vagner
AU - Lima, Mauricio
AU - Xavier, Joilson
AU - Adelino, Talita
AU - Fritsch, Hegger
AU - Castro, Emerson
AU - de Oliveira, Carla
AU - Schuab, Gabriel
AU - Lima, Alex Ranieri Jerônimo
AU - Villalba, Shirley
AU - Gomez de la Fuente, Andrea
AU - Rojas, Analia
AU - Cantero, Cesar
AU - Fleitas, Fatima
AU - Aquino, Carolina
AU - Ojeda, Andrea
AU - Sequera, Guillermo
AU - Torales, Juan
AU - Barrios, Julio
AU - Elias, Maria Carolina
AU - Iani, Felipe C.M.
AU - Ortega, Maria Jose
AU - Gamarra, Maria Liz
AU - Montoya, Romeo
AU - Rodrigues, Evandra Strazza
AU - Kashima, Simone
AU - Sampaio, Sandra Coccuzzo
AU - Coluchi, Norma
AU - Leite, Juliana
AU - Gresh, Lionel
AU - Franco, Leticia
AU - Lourenço, José
AU - Rico, Jairo Mendez
AU - Bispo de Filippis, Ana Maria
AU - Giovanetti, Marta
N1 - Funding Information:
This work was supported by the National Institutes of Health USA grant U01 AI151698 for the United World Arbovirus Research Network (UWARN), by PAHO, FAPESP (2021/11944-6) and by the Mercosur Structural Convergence Fund (FOCEM), FOCEM agreement No. 03/11 Project Research, Education and Biotechnologies Applied to Health (COF 03/11).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/6
Y1 - 2023/6
N2 - Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asunción, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circulating in Paraguay over the past epidemics. Our genomic surveillance activities revealed the co-circulation of multiple DENV serotypes: DENV-1 genotype V, the emerging DENV-2 genotype III, BR4-L2 clade, and DENV-4 genotype II. Results additionally highlight the possible role of Brazil as a source for the international dispersion of different viral strains to other countries in the Americas emphasizing the need for increased surveillance across the borders, for the early detection and response to outbreaks. This, in turn, emphasizes the critical role of genomic surveillance in monitoring and understanding arbovirus transmission and persistence locally and over long distances.
AB - Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asunción, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circulating in Paraguay over the past epidemics. Our genomic surveillance activities revealed the co-circulation of multiple DENV serotypes: DENV-1 genotype V, the emerging DENV-2 genotype III, BR4-L2 clade, and DENV-4 genotype II. Results additionally highlight the possible role of Brazil as a source for the international dispersion of different viral strains to other countries in the Americas emphasizing the need for increased surveillance across the borders, for the early detection and response to outbreaks. This, in turn, emphasizes the critical role of genomic surveillance in monitoring and understanding arbovirus transmission and persistence locally and over long distances.
KW - DENV
KW - Genomic surveillance
KW - Paraguay
KW - Phylodymamics
UR - http://www.scopus.com/inward/record.url?scp=85163974172&partnerID=8YFLogxK
U2 - 10.3390/v15061275
DO - 10.3390/v15061275
M3 - Article
C2 - 37376575
AN - SCOPUS:85163974172
SN - 1999-4915
VL - 15
JO - Viruses
JF - Viruses
IS - 6
M1 - 1275
ER -
