TY - JOUR
T1 - Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases
AU - Pereira Gusmão Maia, Zuinara
AU - Mota Pereira, Felicidade
AU - do Carmo Said, Rodrigo Fabiano
AU - Fonseca, Vagner
AU - Gräf, Tiago
AU - de Bruycker Nogueira, Fernanda
AU - Brandão Nardy, Vanessa
AU - Xavier, Joilson
AU - Lima Maia, Maricelia
AU - Abreu, André L.
AU - Campelo de Albuquerque, Carlos F.
AU - Kleber Oliveira, Wanderson
AU - Croda, Julio
AU - de Filippis, Ana Maria Bispo
AU - Venancio Cunha, Rivaldo
AU - Lourenço, Jose
AU - de Oliveira, Tulio
AU - Faria, Nuno Rodrigues
AU - Junior Alcantara, Luiz Carlos
AU - Giovanetti, Marta
N1 - Funding Information:
This work was supported by the ZiBRA2 project, supported by the Brazilian Ministry of Health (SVS-MS) and the Pan American Organization (OPAS) and founded by CNPq [grant number 440685/2016-8 and 440856/2016-7]; by CAPES [grant number 88887.130716/2016-00, 88881.130825/2016-00 and 88887.130823/2016-00]; by Horizon 2020 Framework Programme [grant number PRES-005-FEX-17-4-2-33]. The Flavivirus Laboratory activities were also supported by Faperj (Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro) under the [grant number E-26/2002.930/2016], by the International Development Research Centre (IDRC) Canada over the [grant number 108411-001] and EU's Horizon 2020 Framework Programme through ZikaPlan and ZikAction under the [grant number 734584 and 734857]. JL was supported by a lectureship from the Department of Zoology, University of Oxford. MG is supported by Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJ; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. The authors thank all personnel from Health Surveillance Systems who coordinated surveillance and helped with data collection and assembly. The authors thank the Director of the Central Health Laboratory of Salvador Bahia, Arabela Leal E Silva de Mello and the Dr. Melissa Barreto Falcão for the clinical evaluation. The authors also thank the Coordinators of each Health Surveillance Unit (from the municipalities of Feira de Santana, Salvador, Camaçari, Coração de Maria, Conceição do Jacuipe, Itamarajú, Ipecaetá and Coaraci).
Publisher Copyright:
© 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Between June 2017 and August 2018, several municipalities located in Bahia state (Brazil) reported a large increase in the number of patients presenting with febrile illness similar to that of arboviral infections. Using a combination of portable whole genome sequencing, molecular clock and epidemiological analyses, we revealed the return of the CHIKV-ECSA genotype into Bahia. Our results show local persistence of lineages in some municipalities and the re-introduction of new epidemiological strains from different Brazilian regions, highlighting a complex dynamic of transmission between epidemic seasons and sampled locations. Estimated climate-driven transmission potential of CHIKV remained at similar levels throughout the years, such that large reductions in the total number of confirmed cases suggests a slow, but gradual accumulation of herd-immunity over the 4 years of the epidemic in Bahia after its introduction in 2014. Bahia remains a reservoir of the genetic diversity of CHIKV in the Americas, and genomic surveillance strategies are essential to assist in monitoring and understanding arboviral transmission and persistence both locally and over large distances.
AB - Between June 2017 and August 2018, several municipalities located in Bahia state (Brazil) reported a large increase in the number of patients presenting with febrile illness similar to that of arboviral infections. Using a combination of portable whole genome sequencing, molecular clock and epidemiological analyses, we revealed the return of the CHIKV-ECSA genotype into Bahia. Our results show local persistence of lineages in some municipalities and the re-introduction of new epidemiological strains from different Brazilian regions, highlighting a complex dynamic of transmission between epidemic seasons and sampled locations. Estimated climate-driven transmission potential of CHIKV remained at similar levels throughout the years, such that large reductions in the total number of confirmed cases suggests a slow, but gradual accumulation of herd-immunity over the 4 years of the epidemic in Bahia after its introduction in 2014. Bahia remains a reservoir of the genetic diversity of CHIKV in the Americas, and genomic surveillance strategies are essential to assist in monitoring and understanding arboviral transmission and persistence both locally and over large distances.
KW - Chikungunya
KW - East-Central-South-African genotype
KW - Northeast Brazil
KW - Portable genome sequencing
KW - Surveillance
UR - http://www.scopus.com/inward/record.url?scp=85077147209&partnerID=8YFLogxK
U2 - 10.1080/22221751.2019.1701954
DO - 10.1080/22221751.2019.1701954
M3 - Letter
C2 - 31880218
AN - SCOPUS:85077147209
SN - 2222-1751
VL - 9
SP - 53
EP - 57
JO - Emerging Microbes and Infections
JF - Emerging Microbes and Infections
IS - 1
ER -
