TY - JOUR
T1 - Risk factors for mortality in end-stage kidney disease patients under online-hemodiafiltration
T2 - Unit-for-Multidisciplinary-Research-in-Biomedicine Summit
AU - Sousa-Martins, Pedro
AU - Moura, Alexandra
AU - Madureira, José
AU - Alija, Pablo
AU - Oliveira, José Gerardo
AU - Lopez, Martin
AU - Filgueiras, Madalena
AU - Amado, Leonilde
AU - Sameiro-Faria, Maria
AU - Miranda, Vasco
AU - Mesquita, Edgar
AU - Teixeira, Laetitia
AU - Santos-Silva, Alice
AU - Lobato, Luísa
AU - Costa, Elísio
PY - 2016/3
Y1 - 2016/3
N2 - End-stage kidney disease (ESRD) patients under dialysis have high mortality rate. Infl ammation, poor nutritional status and disturbances in erythropoiesis and iron metabolism have been reported in these patients. Moreover, there is a growing concern about the health related quality of life (HRQOL) in the context of ESRD. The aim of this work was to study the predictive value of these disturbances, dialysis adequacy and of HRQOL for mortality risk, by performing a three-year follow-up study. Clinical, socio-demographical and analytical data (dialysis adequacy, nutritional status, hematological data, lipid profi le, iron metabolism and infl ammatory markers) were obtained from 236 patients (61.02% male; 67.50 [56.00-75.00] years old) under online-hemodiafi ltration. Patient’s reported HRQOL score was assessed by using the Kidney Disease Quality of Life-Short Form (KDQOL-SF). 54 patients died during the 3 years follow-up period. Our data showed that mean cell hemoglobin concentration (MCHC), transferrin and albumin are signifi cant predictors of mortality. The risk of death was higher in patients presenting lower levels of MCHC (Hazard ratio [HR] = 0.70; 95% confi dence interval [CI] = 0.500-0.984), transferrin (HR = 0.99; 95% CI = 0.982 – 0.998), and albumin (HR = 0.96; 95% CI = 0.938- 0.994). Our study showed that poor nutritional status and an infl ammatory-induced iron depleted erythropoiesis are important factors for mortality in these patients. MCHC, transferrin and albumin may provide useful biomarkers of risk in ESRD patients under OL-HDF.
AB - End-stage kidney disease (ESRD) patients under dialysis have high mortality rate. Infl ammation, poor nutritional status and disturbances in erythropoiesis and iron metabolism have been reported in these patients. Moreover, there is a growing concern about the health related quality of life (HRQOL) in the context of ESRD. The aim of this work was to study the predictive value of these disturbances, dialysis adequacy and of HRQOL for mortality risk, by performing a three-year follow-up study. Clinical, socio-demographical and analytical data (dialysis adequacy, nutritional status, hematological data, lipid profi le, iron metabolism and infl ammatory markers) were obtained from 236 patients (61.02% male; 67.50 [56.00-75.00] years old) under online-hemodiafi ltration. Patient’s reported HRQOL score was assessed by using the Kidney Disease Quality of Life-Short Form (KDQOL-SF). 54 patients died during the 3 years follow-up period. Our data showed that mean cell hemoglobin concentration (MCHC), transferrin and albumin are signifi cant predictors of mortality. The risk of death was higher in patients presenting lower levels of MCHC (Hazard ratio [HR] = 0.70; 95% confi dence interval [CI] = 0.500-0.984), transferrin (HR = 0.99; 95% CI = 0.982 – 0.998), and albumin (HR = 0.96; 95% CI = 0.938- 0.994). Our study showed that poor nutritional status and an infl ammatory-induced iron depleted erythropoiesis are important factors for mortality in these patients. MCHC, transferrin and albumin may provide useful biomarkers of risk in ESRD patients under OL-HDF.
M3 - Meeting Abstract
SN - 0025-7974
VL - 95
SP - 25
EP - 25
JO - Medicine (United States)
JF - Medicine (United States)
IS - 10
M1 - CO33
Y2 - 24 September 2015 through 25 September 2015
ER -
