Risk factors for mortality in end-stage kidney disease patients under online-hemodiafiltration: three-year follow-up study

Pedro Sousa-Martins, Alexandra Moura, José Madureira, Pablo Alija, José Gerardo Oliveira, Martin Lopez, Madalena Filgueiras, Leonilde Amado, Maria Sameiro-Faria, Vasco Miranda, Edgar Mesquita, Laetitia Teixeira, Alice Santos-Silva, Luísa Lobato, Elísio Costa*

*Corresponding author for this work

Research output: Contribution to journalMeeting Abstractpeer-review

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Abstract

End-stage kidney disease (ESRD) patients under dialysis have high mortality rate. Infl ammation, poor nutritional status and disturbances in erythropoiesis and iron metabolism have been reported in these patients. Moreover, there is a growing concern about the health related quality of life (HRQOL) in the context of ESRD. The aim of this work was to study the predictive value of these disturbances, dialysis adequacy and of HRQOL for mortality risk, by performing a three-year follow-up study. Clinical, socio-demographical and analytical data (dialysis adequacy, nutritional status, hematological data, lipid profi le, iron metabolism and infl ammatory markers) were obtained from 236 patients (61.02% male; 67.50 [56.00-75.00] years old) under online-hemodiafi ltration. Patient’s reported HRQOL score was assessed by using the Kidney Disease Quality of Life-Short Form (KDQOL-SF). 54 patients died during the 3 years follow-up period. Our data showed that mean cell hemoglobin concentration (MCHC), transferrin and albumin are signifi cant predictors of mortality. The risk of death was higher in patients presenting lower levels of MCHC (Hazard ratio [HR] = 0.70; 95% confi dence interval [CI] = 0.500-0.984), transferrin (HR = 0.99; 95% CI = 0.982 – 0.998), and albumin (HR = 0.96; 95% CI = 0.938- 0.994). Our study showed that poor nutritional status and an infl ammatory-induced iron depleted erythropoiesis are important factors for mortality in these patients. MCHC, transferrin and albumin may provide useful biomarkers of risk in ESRD patients under OL-HDF.
Original languageEnglish
Article numberCO33
Pages (from-to)25-25
Number of pages1
JournalMedicine (United States)
Volume95
Issue number10
Publication statusPublished - Mar 2016
EventUnit-for-Multidisciplinary-Research-in-Biomedicine Summit - Porto, Portugal
Duration: 24 Sept 201525 Sept 2015

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