TY - JOUR
T1 - Risk factors for mortality in hemodialysis patients
T2 - Two-year follow-up study
AU - Sameiro-Faria, Maria Do
AU - Ribeiro, Sandra
AU - Costa, Elísio
AU - Mendonça, Denisa
AU - Teixeira, Laetitia
AU - Rocha-Pereira, Petronila
AU - Fernandes, João
AU - Nascimento, Henrique
AU - Kohlova, Michaela
AU - Reis, Flávio
AU - Amado, Leonilde
AU - Bronze-Da-Rocha, Elsa
AU - Miranda, Vasco
AU - Quintanilha, Alexandre
AU - Belo, Luís
AU - Santos-Silva, Alice
PY - 2013
Y1 - 2013
N2 - Background. End-stage renal disease (ESRD) patients under hemodialysis (HD) have high mortality rate. Inflammation, dyslipidemia, disturbances in erythropoiesis, iron metabolism, endothelial function, and nutritional status have been reported in these patients. Our aim was to identify any significant association of death with these disturbances, by performing a two-year follow-up study. Methods and Results. A large set of data was obtained from 189 HD patients (55.0% male; 66.4 ± 13.9 years old), including hematological data, lipid profile, iron metabolism, nutritional, inflammatory, and endothelial (dys)function markers, and dialysis adequacy. Results. 35 patients (18.5%) died along the follow-up period. Our data showed that the type of vascular access, C-reactive protein (CRP), and triglycerides (TG) are significant predictors of death. The risk of death was higher in patients using central venous catheter (CVC) (Hazard ratio [HR] =3.03, 95% CI = 1.49-6.13), with higher CRP levels (fourth quartile), compared with those with lower levels (first quartile) (HR = 17.3, 95% CI = 2.40-124.9). Patients with higher TG levels (fourth quartile) presented a lower risk of death, compared with those with the lower TG levels (first quartile) (HR = 0.18, 95% CI = 0.05-0.58). Conclusions. The use of CVC, high CRP, and low TG values seem to be independent risk factors for mortality in HD patients.
AB - Background. End-stage renal disease (ESRD) patients under hemodialysis (HD) have high mortality rate. Inflammation, dyslipidemia, disturbances in erythropoiesis, iron metabolism, endothelial function, and nutritional status have been reported in these patients. Our aim was to identify any significant association of death with these disturbances, by performing a two-year follow-up study. Methods and Results. A large set of data was obtained from 189 HD patients (55.0% male; 66.4 ± 13.9 years old), including hematological data, lipid profile, iron metabolism, nutritional, inflammatory, and endothelial (dys)function markers, and dialysis adequacy. Results. 35 patients (18.5%) died along the follow-up period. Our data showed that the type of vascular access, C-reactive protein (CRP), and triglycerides (TG) are significant predictors of death. The risk of death was higher in patients using central venous catheter (CVC) (Hazard ratio [HR] =3.03, 95% CI = 1.49-6.13), with higher CRP levels (fourth quartile), compared with those with lower levels (first quartile) (HR = 17.3, 95% CI = 2.40-124.9). Patients with higher TG levels (fourth quartile) presented a lower risk of death, compared with those with the lower TG levels (first quartile) (HR = 0.18, 95% CI = 0.05-0.58). Conclusions. The use of CVC, high CRP, and low TG values seem to be independent risk factors for mortality in HD patients.
UR - http://www.scopus.com/inward/record.url?scp=84896956566&partnerID=8YFLogxK
U2 - 10.1155/2013/518945
DO - 10.1155/2013/518945
M3 - Article
C2 - 24347799
AN - SCOPUS:84896956566
SN - 0278-0240
VL - 35
SP - 791
EP - 798
JO - Disease Markers
JF - Disease Markers
IS - 6
ER -