Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling

Viviana P. Ribeiro; Rui L. Reis; J. Miguel Oliveira

doi:10.1016/B978-0-323-91821-3.00012-8

Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling

Viviana P. Ribeiro
, Rui L. Reis
, J. Miguel Oliveira

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The generation of three-dimensional (3D) biological tissues/organs through in vitro models is a promising approach to study and closely simulate the complex biological aspects and interactions within tissues. The combination of cells and engineered matrices to create biologically relevant 3D structures has significantly improved our understanding regarding tissues growth and organization. Different polymers have been used to develop scaffolds engineered and 3D tissues, being silk fibroin (SF)–based biomaterials particularly interesting due to the biologically relevant properties of this protein and successful application in multiple medial fields. This chapter highlights the main benefits of engineering SF-based scaffolds for use as artificial extracellular matrix in 3D in vitro modeling.

Original language	English
Title of host publication	Multiscale cell-biomaterials interplay in musculoskeletal tissue engineering and regenerative medicine
Editors	J. Miguel Oliveira, Rui L. Reis, Sandra Pina
Publisher	Academic Press
Chapter	16
Pages	377-405
Number of pages	29
ISBN (Electronic)	9780323918213
ISBN (Print)	9780323972628
DOIs	https://doi.org/10.1016/B978-0-323-91821-3.00012-8
Publication status	Published - 1 Jan 2023
Externally published	Yes

Keywords

3D models
Biopolymers
ECM
In vitro modeling
Regenerative medicine
Scaffolds
Silk fibroin

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10.1016/B978-0-323-91821-3.00012-8

Cite this

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title = "Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling",

abstract = "The generation of three-dimensional (3D) biological tissues/organs through in vitro models is a promising approach to study and closely simulate the complex biological aspects and interactions within tissues. The combination of cells and engineered matrices to create biologically relevant 3D structures has significantly improved our understanding regarding tissues growth and organization. Different polymers have been used to develop scaffolds engineered and 3D tissues, being silk fibroin (SF)–based biomaterials particularly interesting due to the biologically relevant properties of this protein and successful application in multiple medial fields. This chapter highlights the main benefits of engineering SF-based scaffolds for use as artificial extracellular matrix in 3D in vitro modeling.",

keywords = "3D models, Biopolymers, ECM, In vitro modeling, Regenerative medicine, Scaffolds, Silk fibroin",

author = "Ribeiro, \{Viviana P.\} and Reis, \{Rui L.\} and Oliveira, \{J. Miguel\}",

year = "2023",

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doi = "10.1016/B978-0-323-91821-3.00012-8",

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publisher = "Academic Press",

address = "United States",

}

Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling. / Ribeiro, Viviana P.; Reis, Rui L.; Oliveira, J. Miguel.
Multiscale cell-biomaterials interplay in musculoskeletal tissue engineering and regenerative medicine. ed. / J. Miguel Oliveira; Rui L. Reis; Sandra Pina. Academic Press, 2023. p. 377-405.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling

AU - Ribeiro, Viviana P.

AU - Reis, Rui L.

AU - Oliveira, J. Miguel

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AB - The generation of three-dimensional (3D) biological tissues/organs through in vitro models is a promising approach to study and closely simulate the complex biological aspects and interactions within tissues. The combination of cells and engineered matrices to create biologically relevant 3D structures has significantly improved our understanding regarding tissues growth and organization. Different polymers have been used to develop scaffolds engineered and 3D tissues, being silk fibroin (SF)–based biomaterials particularly interesting due to the biologically relevant properties of this protein and successful application in multiple medial fields. This chapter highlights the main benefits of engineering SF-based scaffolds for use as artificial extracellular matrix in 3D in vitro modeling.

KW - 3D models

KW - Biopolymers

KW - ECM

KW - In vitro modeling

KW - Regenerative medicine

KW - Scaffolds

KW - Silk fibroin

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U2 - 10.1016/B978-0-323-91821-3.00012-8

DO - 10.1016/B978-0-323-91821-3.00012-8

M3 - Chapter

SN - 9780323972628

SP - 377

EP - 405

BT - Multiscale cell-biomaterials interplay in musculoskeletal tissue engineering and regenerative medicine

A2 - Oliveira, J. Miguel

A2 - Reis, Rui L.

A2 - Pina, Sandra

PB - Academic Press

ER -

Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling

Abstract

Keywords

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