Scheme for the selection of measurement uncertainty models in blood establishments' screening immunoassays

Paulo Pereira; James O. Westgard; Pedro Encarnação; Jerard Seghatchian; Gracinda de Sousa

doi:10.1016/j.transci.2014.12.018

Scheme for the selection of measurement uncertainty models in blood establishments' screening immunoassays

Paulo Pereira^*, James O. Westgard, Pedro Encarnação, Jerard Seghatchian, Gracinda de Sousa

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Blood establishments routinely perform screening immunoassays to assess safety of the blood components. As with any other screening test, results have an inherent uncertainty. In blood establishments the major concern is the chance of false negatives, due to its possible impact on patients' health. This article briefly reviews GUM and diagnostic accuracy models for screening immunoassays, recommending a scheme to support the screening laboratories' staffs on the selection of a model considering the intended use of the screening results (i.e., post-transfusion safety). The discussion is grounded on a "risk-based thinking", risk being considered from the blood donor selection to the screening immunoassays. A combination of GUM and diagnostic accuracy models to evaluate measurement uncertainty in blood establishments is recommended.

Original language	English
Pages (from-to)	42-47
Number of pages	6
Journal	Transfusion and Apheresis Science
Volume	52
Issue number	1
DOIs	https://doi.org/10.1016/j.transci.2014.12.018
Publication status	Published - 1 Feb 2015

Keywords

Diagnostic accuracy
GUM
Measurement uncertainty
Post-transfusion safety
Risk assessment
Screening tests

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10.1016/j.transci.2014.12.018

Cite this

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abstract = "Blood establishments routinely perform screening immunoassays to assess safety of the blood components. As with any other screening test, results have an inherent uncertainty. In blood establishments the major concern is the chance of false negatives, due to its possible impact on patients' health. This article briefly reviews GUM and diagnostic accuracy models for screening immunoassays, recommending a scheme to support the screening laboratories' staffs on the selection of a model considering the intended use of the screening results (i.e., post-transfusion safety). The discussion is grounded on a {"}risk-based thinking{"}, risk being considered from the blood donor selection to the screening immunoassays. A combination of GUM and diagnostic accuracy models to evaluate measurement uncertainty in blood establishments is recommended.",

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AU - Pereira, Paulo

AU - Westgard, James O.

AU - Encarnação, Pedro

AU - Seghatchian, Jerard

AU - de Sousa, Gracinda

PY - 2015/2/1

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N2 - Blood establishments routinely perform screening immunoassays to assess safety of the blood components. As with any other screening test, results have an inherent uncertainty. In blood establishments the major concern is the chance of false negatives, due to its possible impact on patients' health. This article briefly reviews GUM and diagnostic accuracy models for screening immunoassays, recommending a scheme to support the screening laboratories' staffs on the selection of a model considering the intended use of the screening results (i.e., post-transfusion safety). The discussion is grounded on a "risk-based thinking", risk being considered from the blood donor selection to the screening immunoassays. A combination of GUM and diagnostic accuracy models to evaluate measurement uncertainty in blood establishments is recommended.

AB - Blood establishments routinely perform screening immunoassays to assess safety of the blood components. As with any other screening test, results have an inherent uncertainty. In blood establishments the major concern is the chance of false negatives, due to its possible impact on patients' health. This article briefly reviews GUM and diagnostic accuracy models for screening immunoassays, recommending a scheme to support the screening laboratories' staffs on the selection of a model considering the intended use of the screening results (i.e., post-transfusion safety). The discussion is grounded on a "risk-based thinking", risk being considered from the blood donor selection to the screening immunoassays. A combination of GUM and diagnostic accuracy models to evaluate measurement uncertainty in blood establishments is recommended.

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KW - Measurement uncertainty

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KW - Risk assessment

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Scheme for the selection of measurement uncertainty models in blood establishments' screening immunoassays

Abstract

Keywords

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