Sequential injection lab-on-valve platform as a miniaturisation tool for solid phase extraction

There is a growing interest in the possibility to perform pre-concentration of analyte and its derivatization with the aim of eliminating interferences, to increase the sensitivity and selectivity of analytical methodologies. The manipulation of the solid phase in conventional analysis may involve the use of relatively large amounts of solid phase. This limitation can be minimized by manipulation in flow systems through the bead injection approach. In this scenario, sequential injection lab-on-valve (SI-LOV) platform has proved to be a powerful tool in the automation of solid phase extraction, and is reviewed in this paper.