TY - JOUR
T1 - Short report
T2 - introduction of chikungunya virus ecsa genotype into the brazilian midwest and its dispersion through the americas
AU - de Oliveira, Elaine Cristina
AU - Fonseca, Vagner
AU - Xavier, Joilson
AU - Adelino, Talita
AU - Claro, Ingra Morales
AU - Fabri, Allison
AU - Macario, Eduardo Marques
AU - Viniski, Ana Elisa
AU - Souza, Claudio Luis Campos
AU - da Costa, Evanil Sebastiana Gomes
AU - de Sousa, Claudia Soares
AU - Duarte, Flávia Guimarães Dias
AU - de Medeiros, Arnaldo Correia
AU - de Albuquerque, Carlos F.Campelo
AU - Cunha, Rivaldo Venancio
AU - De Moura, Noely Fabiana Oliveira
AU - de Filippis, Ana Maria Bispo
AU - de Oliveira, Tulio
AU - Lourenço, José
AU - de Abreu, André Luiz
AU - Alcantara, Luiz Carlos Junior
AU - Giovanetti, Marta
N1 - Funding Information:
This work was supported by Decit/SCTIE/ BrMoH/CNPq (440685/2016-8-421598/2018-2), by CAPES (88887.130716/2016-00), by the European Union’s Horizon 2020 under grant agreements ZIKACTION (734857) and ZIKAPLAN (734548), by the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro – FAPERJ (E-26/ 2002.930/2016), the International Development Research Centre (IDRC) Canada (108411-001). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.We thank all personnel from Health Surveillance System from the Mato Grosso and Brazilian Ministry of Health that helped with samples, sources, epidemiological data collection and transportation of reagents.
Publisher Copyright:
© 2021 de Oliveira et al.
PY - 2021/4
Y1 - 2021/4
N2 - Since introduction into Brazil in 2014, chikungunya virus (CHIKV) has presented sustained transmission, although much is unknown about its circulation in the midwestern states. Here, we analyze 24 novel partial and near complete CHIKV genomes from Cuiaba, an urban metropolis located in the Brazilian midwestern state of Mato Grosso (MT). Nanopore technology was used for sequencing CHIKV complete genomes. Phylogenetic and epidemiological approaches were used to explore the recent spatio-temporal evolution and spread of the CHIKV-ECSA genotype in Midwest Brazil as well as in the Americas. Epidemiological data revealed a reduction in the number of reported cases over 2018– 2020, likely as a consequence of a gradual accumulation of herd-immunity. Phylogeographic reconstructions revealed that at least two independent introductions of the ECSA lineage occurred in MT from a dispersion event originating in the northeastern region and suggest that the midwestern Brazilian region appears to have acted as a source of virus transmission towards Paraguay, a bordering South American country. Our results show a complex dynamic of transmission between epidemic seasons and suggest a possible role of Brazil as a source for international dispersion of the CHIKV-ECSA genotype to other countries in the Americas.
AB - Since introduction into Brazil in 2014, chikungunya virus (CHIKV) has presented sustained transmission, although much is unknown about its circulation in the midwestern states. Here, we analyze 24 novel partial and near complete CHIKV genomes from Cuiaba, an urban metropolis located in the Brazilian midwestern state of Mato Grosso (MT). Nanopore technology was used for sequencing CHIKV complete genomes. Phylogenetic and epidemiological approaches were used to explore the recent spatio-temporal evolution and spread of the CHIKV-ECSA genotype in Midwest Brazil as well as in the Americas. Epidemiological data revealed a reduction in the number of reported cases over 2018– 2020, likely as a consequence of a gradual accumulation of herd-immunity. Phylogeographic reconstructions revealed that at least two independent introductions of the ECSA lineage occurred in MT from a dispersion event originating in the northeastern region and suggest that the midwestern Brazilian region appears to have acted as a source of virus transmission towards Paraguay, a bordering South American country. Our results show a complex dynamic of transmission between epidemic seasons and suggest a possible role of Brazil as a source for international dispersion of the CHIKV-ECSA genotype to other countries in the Americas.
UR - http://www.scopus.com/inward/record.url?scp=85104397333&partnerID=8YFLogxK
U2 - 10.1371/journal.pntd.0009290
DO - 10.1371/journal.pntd.0009290
M3 - Article
C2 - 33861753
AN - SCOPUS:85104397333
SN - 1935-2727
VL - 15
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
IS - 4
M1 - e0009290
ER -
