Significance of fast and simple determination of catecholamines and their metabolites in patients with Down syndrome

L. I. B. Silva*, M. E. Pereira, A. C. Duarte, A. M. Gomes, M. M. Pintado, H. Pinheiro, D. Moura, A. C. Freitas, T. A. P. Rocha-Santos

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The excretion of catecholamines and their precursor and the major dopamine metabolite in urine was studied in 3 to 18 year old Down Syndrome (DS) subjects. A drenaline and noradrenaline concentrations were used as indicators of physiological stress and dopamine, L-3,4-dihydroxyphenylalanine (L-DOPA), and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were used as indicators of the contribution of the dopaminergic system to the kidney function. An optical fiber biosensor was used with a view to assess the significance of such of fast and simple determination of catecholamines and their precursor and metabolite in DS patients.
Original languageEnglish
Title of host publicationTechnology and Medical Sciences - TMSi 2010
PublisherCRC Press
Pages257-260
Number of pages4
Edition
ISBN (Electronic)9780203816592, 9780429212932
ISBN (Print)9781138112896, 9780415668224
DOIs
Publication statusPublished - 11 Jan 2011
Event6th International Conference on Technology and Medical Sciences - Universidade do porto, Porto, Portugal
Duration: 21 Oct 201023 Oct 2010

Publication series

NameTechnology and Medical Sciences, TMSi 2010 - Proceedings of the 6th International Conference on Technology and Medical Sciences

Conference

Conference6th International Conference on Technology and Medical Sciences
Abbreviated titleTMSi 2010
Country/TerritoryPortugal
CityPorto
Period21/10/1023/10/10

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