Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration

Viviana P. Ribeiro*, Sandra Pina, J. Miguel Oliveira, Rui L. Reis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

44 Citations (Scopus)

Abstract

Osteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structures alone or in combination with cells and bioactive molecules bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties. Owing the potential as scaffolding materials, natural and synthetic polymers, bioceramics, and composites have been employed. Particularly, significance is attributed to the natural-based biopolymer silk fibroin from the Bombyx mori silkworm, considering its unique mechanical and biological properties. The significant studies on silk fibroin-based structures, namely hydrogels and scaffolds, towards bone, cartilage, and osteochondral tissue repair and regeneration are overviewed herein. The developed biomimetic strategies, processing methodologies, and final properties of the structures are summarized and discussed in depth.
Original languageEnglish
Title of host publicationOsteochondral tissue engineering
Subtitle of host publicationnanotechnology, scaffolding-related developments and translation
EditorsJ. Miguel Oliveira, Sandra Pina, Rui L. Reis, Julio San Roman
PublisherSpringer New York LLC
Pages305-325
Number of pages21
ISBN (Electronic)9783319767116
ISBN (Print)9783319767109, 9783030095611
DOIs
Publication statusPublished - 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1058
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Hydrogels
  • Osteochondral regeneration
  • Scaffolds
  • Silk fibroin

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