TY - CHAP
T1 - Silk Fibroin-Based Hydrogels and Scaffolds for Osteochondral Repair and Regeneration
AU - Ribeiro, Viviana P.
AU - Pina, Sandra
AU - Oliveira, J. Miguel
AU - Reis, Rui L.
N1 - Funding Information:
Acknowledgments The authors thank to the project FROnTHERA (NORTE-01-0145-FEDER-000023), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). The financial support from the Portuguese Foundation for Science and Technology to Hierarchitech project (M-ERA-NET/0001/2014), for the fellowship grant (SFRH/ BPD/113806/2015) and for the fund provided under the program Investigador for J. M. Oliveira (IF/00423/2012 and IF/01285/2015) are also greatly acknowledged.
Publisher Copyright:
© 2018, Springer International Publishing AG, part of Springer Nature.
PY - 2018
Y1 - 2018
N2 - Osteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structures alone or in combination with cells and bioactive molecules bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties. Owing the potential as scaffolding materials, natural and synthetic polymers, bioceramics, and composites have been employed. Particularly, significance is attributed to the natural-based biopolymer silk fibroin from the Bombyx mori silkworm, considering its unique mechanical and biological properties. The significant studies on silk fibroin-based structures, namely hydrogels and scaffolds, towards bone, cartilage, and osteochondral tissue repair and regeneration are overviewed herein. The developed biomimetic strategies, processing methodologies, and final properties of the structures are summarized and discussed in depth.
AB - Osteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structures alone or in combination with cells and bioactive molecules bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties. Owing the potential as scaffolding materials, natural and synthetic polymers, bioceramics, and composites have been employed. Particularly, significance is attributed to the natural-based biopolymer silk fibroin from the Bombyx mori silkworm, considering its unique mechanical and biological properties. The significant studies on silk fibroin-based structures, namely hydrogels and scaffolds, towards bone, cartilage, and osteochondral tissue repair and regeneration are overviewed herein. The developed biomimetic strategies, processing methodologies, and final properties of the structures are summarized and discussed in depth.
KW - Hydrogels
KW - Osteochondral regeneration
KW - Scaffolds
KW - Silk fibroin
UR - http://www.scopus.com/inward/record.url?scp=85045990026&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-76711-6_14
DO - 10.1007/978-3-319-76711-6_14
M3 - Chapter
C2 - 29691828
T3 - Advances in Experimental Medicine and Biology
SP - 305
EP - 325
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -