Silk fibroin-based hydrogels and scaffolds for osteochondral repair and regeneration

Viviana P. Ribeiro*, Sandra Pina, J. Miguel Oliveira, Rui L. Reis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

36 Citations (Scopus)


Osteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structures alone or in combination with cells and bioactive molecules bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties. Owing the potential as scaffolding materials, natural and synthetic polymers, bioceramics, and composites have been employed. Particularly, significance is attributed to the natural-based biopolymer silk fibroin from the Bombyx mori silkworm, considering its unique mechanical and biological properties. The significant studies on silk fibroin-based structures, namely hydrogels and scaffolds, towards bone, cartilage, and osteochondral tissue repair and regeneration are overviewed herein. The developed biomimetic strategies, processing methodologies, and final properties of the structures are summarized and discussed in depth.

Original languageEnglish
Title of host publicationAdvances in experimental medicine and biology
PublisherSpringer New York LLC
Number of pages21
Publication statusPublished - 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Hydrogels
  • Osteochondral regeneration
  • Scaffolds
  • Silk fibroin


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