@inproceedings{707d0632cd8e4830a0f2707e78992f37,
title = "Silk fibroin/nano-CaP bilayered scaffolds for osteochondral tissue engineering",
abstract = "In this study, bilayered silk and silk/nano-CaP scaffolds were developed for osteochondral (OC) tissue engineering. Aqueous silk solution (16 wt.%) was used for preparation of the cartilage-like layer and, for generation of the silk/nano-CaP suspension and the bottom layer (CaP/Silk: 16 wt.%). The scaffolds were formed by using salt-leaching/lyophilization approach. The scanning electron microscopy revealed that the both layers presented porous structure and integrated well. Micro-computed tomography images confirmed that the CaP phase was only retained in the silk/nano-CaP layer. The hydration degree and mechanical properties of the bilayered scaffold were comparable to the ones of each single layer. The apatite crystal formation was limited to the silk/nano-CaP layer, when soaking the scaffold in a simulated body fluid solution, which is a must for the application of the developed scaffolds in OC tissue engineering.",
keywords = "Bilayered scaffold, Nano calcium phosphate, Osteochondral tissue engineering, Silk fibroin",
author = "Yan, {Le Ping} and Oliveira, {Joaquim M.} and Oliveira, {Ana L.} and Reis, {Rui L.}",
year = "2014",
doi = "10.4028/www.scientific.net/KEM.587.245",
language = "English",
isbn = "9783037858998",
series = "Key Engineering Materials",
publisher = "Trans Tech Publications Ltd",
pages = "245--248",
booktitle = "Bioceramics 25",
address = "Sweden",
note = "25th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2013 ; Conference date: 07-11-2013 Through 10-11-2013",
}