Silver-containing calcium phosphate materials of marine origin with antibacterial activity

C. Piccirillo, R. C. Pullar, D. M. Tobaldi, P. M. Lima Castro, M. M. Estevez Pintado*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Hydroxyapatite (Ca10(PO4)6(OH)2 - HAp) is a common material for bone replacement in artificial implants and prostheses, due to its high biocompatibility. In this work we report about the preparation of HAp-based materials of marine origin with antibacterial properties. Bones from cod fish (Gadhus morua) were treated with a dilute AgNO3 solution, to obtain HAp-containing samples with silver as a minor component. The samples were characterised by XRD, FT-IR spectroscopy and SEM, indicating the presence of HAp, β-TCP and some metallic silver. The determination of unit cell parameters, however, indicated that the majority of silver is substituted in the β-TCP lattice in ionic form. The antibacterial activity of these materials was tested towards both Gram-positive and Gram-negative bacterias; results showed that the material is very effective with Gram-negative strains such as Escherichia coli (inactivation rates of 99.82% and 99.999% after 2 and 5 h, respectively) and had a smaller but still significant effect on Gram-positive MRSA (91% inactivation rate). These results show the potentials of these samples as infection-resistant bone replacement materials.
Original languageEnglish
Article number10523
Pages (from-to)10152-10159
Number of pages8
JournalCeramics International
Volume41
Issue number8
DOIs
Publication statusPublished - 1 Sept 2015

Keywords

  • Antibacterial
  • Natural hydroxyapatite
  • Silver
  • β-tricalcium phosphate

Fingerprint

Dive into the research topics of 'Silver-containing calcium phosphate materials of marine origin with antibacterial activity'. Together they form a unique fingerprint.

Cite this