Solid lipid nanoparticles (SLN™)

Eliana B. Souto; Joana F. Fangueiro; Rainer H. Müller

doi:10.1007/978-1-4614-9164-4_5

Solid lipid nanoparticles (SLN^™)

Eliana B. Souto^*, Joana F. Fangueiro, Rainer H. Müller

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

22 Citations (Scopus)

Abstract

Solid lipid nanoparticles (SLN^™) are a new generation of drug delivery systems being exploited for several drugs since the nineties. These particles can be composed of different types of solid lipids, such as glycerides, waxes, and fatty acids, and stabilized by a wide range of surfactants. In the present chapter, the chemical structure, production methodology, and physicochemical characterization are systematically discussed. Parameters such as particle size, distribution, polymorphic behaviour, and crystallization are required to characterize SLN and may predict their in vitro stability and in vivo profile, therefore structural parameters can influence the biopharmaceutical properties. The use of SLN for drug delivery is also dependent on their toxicological profile in vitro. Nanotoxicology is also discussed addressing the key points that may limit the clinical use of SLN.

Original language	English
Title of host publication	Fundamentals of Pharmaceutical Nanoscience
Publisher	Springer New York LLC
Pages	91-116
Number of pages	26
ISBN (Electronic)	9781461491644
ISBN (Print)	9781461491637
DOIs	https://doi.org/10.1007/978-1-4614-9164-4_5
Publication status	Published - 1 Jan 2013
Externally published	Yes

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AB - Solid lipid nanoparticles (SLN™) are a new generation of drug delivery systems being exploited for several drugs since the nineties. These particles can be composed of different types of solid lipids, such as glycerides, waxes, and fatty acids, and stabilized by a wide range of surfactants. In the present chapter, the chemical structure, production methodology, and physicochemical characterization are systematically discussed. Parameters such as particle size, distribution, polymorphic behaviour, and crystallization are required to characterize SLN and may predict their in vitro stability and in vivo profile, therefore structural parameters can influence the biopharmaceutical properties. The use of SLN for drug delivery is also dependent on their toxicological profile in vitro. Nanotoxicology is also discussed addressing the key points that may limit the clinical use of SLN.

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Solid lipid nanoparticles (SLN^™)

Abstract

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