Especiação de cobre e zinco em urina - importância dos metais em doenças neurodegenerativas

Translated title of the contribution: Speciation of copper and zinc in urine - importance of metals in neurodegenerative diseases

Maria Fernanda C. Leal*, Rita I. L. Catarino, Adriana M. Pimenta, Maria Renata S. Souto, Tatiana S.N. Pinheiro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
1 Downloads

Abstract

Metals such as copper and zinc are essential for the development and maintenance of numerous enzymatic activities, mitochondrial functions, neurotransmission, and also for memorization and learning. However, disruption in their homeostasis can cause neurodegenerative disorders such as the Alzheimer and Parkinson diseases. In this work, the speciation of copper and zinc in urine samples was carried out. To this end, free and total metal concentrations were determined by square wave anodic stripping voltammetry using a glassy carbon electrode coated with bismuth film. The digestion of the samples was performed in a microwave with the addition of oxidant reagents.
Translated title of the contributionSpeciation of copper and zinc in urine - importance of metals in neurodegenerative diseases
Original languagePortuguese
Pages (from-to)1985-1990
Number of pages6
JournalQuimica Nova
Volume35
Issue number10
DOIs
Publication statusPublished - 12 Nov 2012

Keywords

  • Metals
  • Neurodegenerative diseases
  • Stripping voltammetry

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