TY - JOUR
T1 - SRF in angiogenesis
T2 - Branching the vascular system
AU - Franco, Claudio A.
AU - Li, Zhenlin
N1 - Funding Information:
This work was supported by the french National Research Agency.
PY - 2009
Y1 - 2009
N2 - Cell cytoskeleton proteins are fundamental to cell shape, cell adhesion and cell motility, and therefore play an important role during angiogenesis. One of the major regulators of cytoskeletal protein expression is serum response factor (SRF), a MADS-box transcription factor that regulates multiple genes implicated in cell growth, migration, cytoskeletal organization, energy metabolism and myogenesis. Recent data have demonstrated a crucial role of SRF downstream of VEGF and FGF signalling during sprouting angiogenesis, regulating endothelial cell (EC) migration, actin polymerisation, tip cell morphology, EC junction assembly and vascular integrity. Here, we review the role of SRF in the regulation of angiogenesis and EC function, integrate SRF function into a broader mechanism regulating branching morphogenesis, and discuss future directions and perspectives of SRF in EC biology.
AB - Cell cytoskeleton proteins are fundamental to cell shape, cell adhesion and cell motility, and therefore play an important role during angiogenesis. One of the major regulators of cytoskeletal protein expression is serum response factor (SRF), a MADS-box transcription factor that regulates multiple genes implicated in cell growth, migration, cytoskeletal organization, energy metabolism and myogenesis. Recent data have demonstrated a crucial role of SRF downstream of VEGF and FGF signalling during sprouting angiogenesis, regulating endothelial cell (EC) migration, actin polymerisation, tip cell morphology, EC junction assembly and vascular integrity. Here, we review the role of SRF in the regulation of angiogenesis and EC function, integrate SRF function into a broader mechanism regulating branching morphogenesis, and discuss future directions and perspectives of SRF in EC biology.
KW - Angiogenesis
KW - Endothelial cell
KW - FGF
KW - SRF
KW - Vascular morphogenesis
KW - VEGF
UR - http://www.scopus.com/inward/record.url?scp=68249107144&partnerID=8YFLogxK
U2 - 10.4161/cam.3.3.8291
DO - 10.4161/cam.3.3.8291
M3 - Comment/debate
C2 - 19287204
SN - 1933-6918
VL - 3
SP - 264
EP - 267
JO - Cell Adhesion and Migration
JF - Cell Adhesion and Migration
IS - 3
ER -