TY - GEN
T1 - Study of bone repair in rat dental socket after implantation of porous granules of beta-tricalcium phosphate (β-TCP) and magnesiumsubstituted beta-tricalcium phosphate (β-TCMP)
AU - Yassuda-Mattos, Debora Helena
AU - Costa, Neusa Motta Freitas
AU - Tavares, Débora
AU - Fernandes, Gustavo Vicentis de Oliveira
AU - Alves, Adriana Therezinha
AU - Granjeiro, José Mauro
AU - Soares, Glória Dulce de Almeida
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Porous granules were obtained through a route using a mixture of calcium phosphate powder with sodium alginate solution. The sintered β-TCP and β-TCMP granules with diameters ranging from 250 μm to 500 μm were implanted into dental alveoli of 30 rats (Rattus norvegicus). The animals were divided in three groups: group I (control, no treatment), group II (β-TCP) and group III (β-TCMP); the sacrifices occurred at 7 and 21 days (n=5/group/period). Histological and histomorphometric analysis were performed to observe and measure connective tissue, bone neoformation and biomaterial areas. Most animals showed acute inflammatory response with many neutrophil granulocytes and foreign body giant multinucleated cells associated to both biomaterials, at 7 and 21 days. The utilization of sodium alginate as additive in the porous granules might explain these results. Fourier-transformed infrared spectroscopy (FTIR) pointed out residue in the granules surface that could exacerbate the inflammatory response. Additional studies are in course to confirm such hypothesis.
AB - Porous granules were obtained through a route using a mixture of calcium phosphate powder with sodium alginate solution. The sintered β-TCP and β-TCMP granules with diameters ranging from 250 μm to 500 μm were implanted into dental alveoli of 30 rats (Rattus norvegicus). The animals were divided in three groups: group I (control, no treatment), group II (β-TCP) and group III (β-TCMP); the sacrifices occurred at 7 and 21 days (n=5/group/period). Histological and histomorphometric analysis were performed to observe and measure connective tissue, bone neoformation and biomaterial areas. Most animals showed acute inflammatory response with many neutrophil granulocytes and foreign body giant multinucleated cells associated to both biomaterials, at 7 and 21 days. The utilization of sodium alginate as additive in the porous granules might explain these results. Fourier-transformed infrared spectroscopy (FTIR) pointed out residue in the granules surface that could exacerbate the inflammatory response. Additional studies are in course to confirm such hypothesis.
KW - Biomaterials
KW - Bone repair
KW - Mg-substituted β-TCP
KW - Porous granules
KW - β-tcp
UR - http://www.scopus.com/inward/record.url?scp=81555206809&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.493-494.263
DO - 10.4028/www.scientific.net/KEM.493-494.263
M3 - Conference contribution
AN - SCOPUS:81555206809
SN - 9783037852552
T3 - Key Engineering Materials
SP - 263
EP - 268
BT - Bioceramics 23
PB - Trans Tech Publications Ltd
T2 - 23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011
Y2 - 6 November 2011 through 9 November 2011
ER -