Supercritical fluid extraction and hydrodistillation for the recovery of bioactive compounds from Lavandula viridis L'Hér

Patrícia Costa, Clara Grosso, Sandra Gonçalves, Paula B. Andrade, Patrícia Valentão, M. Gabriela Bernardo-Gil, Anabela Romano*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


The chemical profiles of bioactive essential oil and extracts obtained by hydrodistillation (HD) and supercritical fluid extraction (SFE), respectively, from Lavandula viridis were compared. The SFE was performed at 40 °C and at extraction pressures of 12 or 18 MPa in two different separators. Evaluation of the essential oil and SFE extracts by GC-FID and GC-IT-MS revealed that oxygen-containing monoterpenes were the major constituents in both cases, but there were important differences between the chemical profiles produced by the different extraction techniques. More compounds were isolated by HD but higher yields were achieved by SFE. Camphor was the main component identified in the essential oil (31.59 ± 1.32%), and in extracts from the first (1.61 ± 0.34%) and second SFE separators (22.48 ± 1.49%) at 12 MPa. In contrast, the first separator SFE extract at 18 MPa (heavy compounds) was dominated by myrtenol (5.38 ± 2.04%) and camphor (4.81 ± 1.93%), whereas the second separator SFE extract (volatiles) was dominated by verbenone (13.97 ± 5.27%). The essential oil and heavy compound extracts from the first separator possessed antioxidant and anti-cholinesterase activities. Our data show that phytochemicals from the aerial parts of L. viridis could be developed as natural antioxidant and anti-cholinesterase drugs, with particular applications in the symptomatic treatment of Alzheimer's disease.

Original languageEnglish
Pages (from-to)112-121
Number of pages10
JournalFood Chemistry
Issue number1
Publication statusPublished - 1 Nov 2012


  • Alzheimer's disease
  • Anti-cholinesterase
  • Antioxidants
  • Essential oil
  • Lavandula viridis
  • SFE extracts


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