TY - JOUR
T1 - Sustainable natural gums for industrial application
T2 - physiochemical and texturometric evaluation
AU - Ferreira, Susana Raquel dos Santos
AU - Mesquita, Martha Vitória Norberto
AU - Sá, Laisa Lis Fontinele de
AU - Nogueira, Naiane Carvalho
AU - Rizzo, Márcia dos Santos
AU - Silva-Filho, Edson Cavalcanti
AU - Costa, Marcília Pinheiro da
AU - Ribeiro, Alessandra Braga
N1 - Funding Information:
The authors gratefully acknowledge the financial support from the National Council for Scientific and Technological Development (CNPq) Chamada CNPq N° 12/2016 - Bolsas de Produtividade em Pesquisa - PQ, N. 307460/2016-9 , Brazil; and the Foundation for Research Support by the State of Piauí (FAPEPI) , Brazil Edital No 006/2014 – FAPEPI/CNPq, Brazil.
Funding Information:
The authors gratefully acknowledge the financial support from the National Council for Scientific and Technological Development (CNPq) Chamada CNPq N? 12/2016 - Bolsas de Produtividade em Pesquisa - PQ, N. 307460/2016-9, Brazil; and the Foundation for Research Support by the State of Piau? (FAPEPI), Brazil Edital No 006/2014 ? FAPEPI/CNPq, Brazil.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/12
Y1 - 2019/12
N2 - In this study, the cashew gum (Anacardium occidentale Linn) (GCa) and chicha gum (Sterculia striata) (GCh) were characterized and used in the development of tables and hydrogels. For this purpose, the gums were initially characterized by XRD, FTIR, TG, and DSC, and flow property. The tablets obtained were evaluated for hardness, swelling, and mucoadhesiveness, while the hydrogels developed were assessed by texturometric assays. The physicochemical analysis demonstrated that the GCa and GCh gums present microcrystalline and amorphous structures, respectively. Both were classified as fine powders and presented proper flowability and compressibility to the development of tables. The tablets containing GCa and GCh presented mucoadhesion strength of 2.10 ± 0.31 N and 1.72 ± 0.30 N, respectively. Both tablets exhibited similar mucoadhesion behavior to the polymers conventionally used for this purpose, such as the carbomers. However, there was an evident difference in the swelling process, in which the GCa table presented high erosion and low swelling, while the GCh tables presented a crescent and linear swelling behavior and no erosion process in the observed time. GCh hydrogel was the most easily obtained and presented the best thick consistency and adhesion compatible with topical formulations. Thus, based on the results found, we can conclude that both natural polymers are promising excipients in the development of adhesive and control drug delivery formulations.
AB - In this study, the cashew gum (Anacardium occidentale Linn) (GCa) and chicha gum (Sterculia striata) (GCh) were characterized and used in the development of tables and hydrogels. For this purpose, the gums were initially characterized by XRD, FTIR, TG, and DSC, and flow property. The tablets obtained were evaluated for hardness, swelling, and mucoadhesiveness, while the hydrogels developed were assessed by texturometric assays. The physicochemical analysis demonstrated that the GCa and GCh gums present microcrystalline and amorphous structures, respectively. Both were classified as fine powders and presented proper flowability and compressibility to the development of tables. The tablets containing GCa and GCh presented mucoadhesion strength of 2.10 ± 0.31 N and 1.72 ± 0.30 N, respectively. Both tablets exhibited similar mucoadhesion behavior to the polymers conventionally used for this purpose, such as the carbomers. However, there was an evident difference in the swelling process, in which the GCa table presented high erosion and low swelling, while the GCh tables presented a crescent and linear swelling behavior and no erosion process in the observed time. GCh hydrogel was the most easily obtained and presented the best thick consistency and adhesion compatible with topical formulations. Thus, based on the results found, we can conclude that both natural polymers are promising excipients in the development of adhesive and control drug delivery formulations.
KW - Biopolymer
KW - Cashew gum
KW - Chicha gum
KW - Plant exudates
UR - http://www.scopus.com/inward/record.url?scp=85073025202&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2019.101306
DO - 10.1016/j.jddst.2019.101306
M3 - Article
AN - SCOPUS:85073025202
SN - 1773-2247
VL - 54
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 101306
ER -