Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration

Beatriz G. Bernardes, Anabela Veiga, Joana Barros, Carlos A. García-González, Ana Leite Oliveira*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems in promoting the controlled release of pharmaceuticals and bioactive agents in the context of wound healing and skin regeneration. Silk fibroin and sericin are derived from well-established silkworm production and constitute a unique biocompatible and biodegradable protein platform for the development of drug delivery systems. The controlled release of therapeutic compounds from silk-based particulate systems not only ensures optimal bioavailability but also addresses the challenges associated with conventional delivery methods. The multifaceted benefits of silk proteins, including their inherent biocompatibility, versatility, and sustainability, are explored in this review. Furthermore, the intricate mechanisms by which controlled drug release takes place from silk-based carriers are discussed.
Original languageEnglish
Article number3133
Number of pages31
JournalInternational Journal of Molecular Sciences
Volume25
Issue number6
DOIs
Publication statusPublished - 8 Mar 2024

Keywords

  • Silk proteins
  • Drug carriers
  • Particulate systems
  • Wound healing
  • Tissue engineering

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