TY - JOUR
T1 - Synthesis, characterization and photodynamic activity against bladder cancer cells of novel triazole-porphyrin derivatives
AU - Gomes, Ana T.P.C.
AU - Fernandes, Rosa
AU - Ribeiro, Carlos F.
AU - Tomé, João P.C.
AU - Neves, Maria G.P.M.S.
AU - da Silva, Fernando de C.
AU - Ferreira, Vítor F.
AU - Cavaleiro, José A.S.
N1 - Funding Information:
Funding: The authors are grateful to University of Aveiro and FCT/MCT for the financial support for QOPNA research Unit (FCT UID/QUI/00062/2019) and LAQV-REQUIMTE (UIDB/50006/2020) through national funds. Thanks are also due to FCT/MCT for the financial support of iCBR and CIBB units (TDC/QEQQOR/1273/2012; UID/NEU/04539/2019 FCT UID/QUI/00062/2013) and CQE unit (UIDB/00100/2020), COMPETE-FEDER (POCI-01-0145-FEDER-007440) and Centro 2020 Regional Operational Programme: HEALTHYAGING 2020 (CENTRO-01-0145-FEDER-000012) for funding. Ana Gomes also thanks FCT for the post-doctoral grant (SFRH/BPD/79521/2011).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
PY - 2020
Y1 - 2020
N2 - Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.
AB - Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.
KW - Human bladder cancer cells
KW - Human retinal pigment epithelial cells
KW - Photodynamic therapy
KW - Polyvinylpyrrolidone
KW - Porphyrin
KW - Triazole
UR - http://www.scopus.com/inward/record.url?scp=85082809318&partnerID=8YFLogxK
U2 - 10.3390/molecules25071607
DO - 10.3390/molecules25071607
M3 - Article
C2 - 32244514
AN - SCOPUS:85082809318
SN - 1420-3049
VL - 25
JO - Molecules
JF - Molecules
IS - 7
M1 - 1607
ER -
