Synthesis, characterization and photodynamic activity against bladder cancer cells of novel triazole-porphyrin derivatives

Ana T.P.C. Gomes*, Rosa Fernandes, Carlos F. Ribeiro, João P.C. Tomé, Maria G.P.M.S. Neves, Fernando de C. da Silva, Vítor F. Ferreira, José A.S. Cavaleiro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.
Original languageEnglish
Article number1607
JournalMolecules
Volume25
Issue number7
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Human bladder cancer cells
  • Human retinal pigment epithelial cells
  • Photodynamic therapy
  • Polyvinylpyrrolidone
  • Porphyrin
  • Triazole

Fingerprint

Dive into the research topics of 'Synthesis, characterization and photodynamic activity against bladder cancer cells of novel triazole-porphyrin derivatives'. Together they form a unique fingerprint.

Cite this