Abstract
This work reports the synthesis of porphyrin derivatives with potential leishmanicidal activity. The β-substituents contain amine/imine- heterocyclic features. Molecular docking simulations of these compounds to a model of the enzyme arginase from Leishmania amazonensis were carried out. Singlet oxygen generation studies have been also considered. The obtained leishmanicidal properties show that these compounds can be considered as prototypes for future cutaneous antileishmaniasis agents. This publication reports the synthesis of porphyrin derivatives bearing amino-heterocyclic moieties at a β position. Molecular modeling and docking calculations show that all compounds synthesized have high affinity values to leishmanial arginase. These derivatives are potential leishmaniasis agents.
Original language | English |
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Pages (from-to) | 1485-1493 |
Number of pages | 9 |
Journal | European Journal of Organic Chemistry |
Issue number | 8 |
DOIs | |
Publication status | Published - Mar 2013 |
Externally published | Yes |
Keywords
- Antiprotozoal agents
- Drug design
- Medicinal chemistry
- Nitrogen heterocycles
- Photosensitizers
- Porphyrinoids