The biochemistry of saliva throughout pregnancy

Rute Rio, Álvaro Azevedo, Liliana Simões-Silva, Jorge Marinho, Mário Jorge Silva, Benedita Sampaio-Maia

Research output: Contribution to journalArticlepeer-review



BACKGROUND & OBJECTIVE: Sialometric and sialochemical analyses during pregnancy are not consistent, and frequently contradictory in terms of salivary flow rate, pH, and concentration of calcium, phosphorous, sodium, potassium, chloride, glucose and α-amylase. We, therefore, measured the evolution of these parameters throughout pregnancy. METHOD: A cross-sectional study compared sialometric and sialochemical analyses of 30 pregnant women vs. 30 age-matched non-pregnant women, and a longitudinal study evaluated the pregnant women in the first and third trimester of pregnancy. RESULTS: Pregnant women presented acidic non-stimulated saliva, but neutral stimulated saliva pH, and no relevant changes in salivary flow rate. Scialochemical analysis showed decreased calcium levels, increased phosphate levels, and a progressive decrease in glucose levels throughout pregnancy.
CONCLUSION: Pregnancy significantly changes the oral biochemical milieu, creating a favorable environment for the development of oral pathology, in particular, dental caries.
Translated title of the contributionO efeito da gravidez sobre a bioquímica salivar
Original languageEnglish
Number of pages6
Issue number5
Publication statusPublished - 1 Jan 2015


  • Saliva
  • Pregnancy
  • PH
  • Calcium
  • Phosphorous
  • Glucose


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