@article{1f580f7d3ba34f42b7c0595cee5fcab4,
title = "The impact of viral mutations on recognition by SARS-CoV-2 specific T cells",
abstract = "We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.",
keywords = "Immune response, Immunology, Molecular biology, Phylogenetics, Virology",
author = "{COVID-19 Genomics UK (COG-UK) consortium} and {ISARIC4C Investigators} and Silva, {Thushan I. de} and Guihai Liu and Lindsey, {Benjamin B.} and Danning Dong and Moore, {Shona C.} and Hsu, {Nienyun Sharon} and Dhruv Shah and Dannielle Wellington and Mentzer, {Alexander J.} and Adrienn Angyal and Rebecca Brown and Parker, {Matthew D.} and Zixi Ying and Xuan Yao and Lance Turtle and Susanna Dunachie and Aanensen, {David M.} and Khalil Abudahab and Helen Adams and Alexander Adams and Safiah Afifi and Dinesh Aggarwal and Ahmad, {Shazaad S.Y.} and Louise Aigrain and Adela Alcolea-Medina and Alikhan, {Nabil Fareed} and Elias Allara and Roberto Amato and Tara Annett and Stephen Aplin and Ariani, {Cristina V.} and Hibo Asad and Amy Ash and Paula Ashfield and Fiona Ashford and Laura Atkinson and Attwood, {Stephen W.} and Cressida Auckland and Alp Aydin and Baker, {David J.} and Paul Baker and Balcazar, {Carlos E.} and Jonathan Ball and Barrett, {Jeffrey C.} and Magdalena Barrow and Edward Barton and Matthew Bashton and Bassett, {Andrew R.} and Rahul Batra and Marta Gallis and Maini, {Mala K.} and Graham Ogg and Knight, {Julian C.} and Yanchun Peng and Rowland-Jones, {Sarah L.} and Tao Dong",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = nov,
day = "19",
doi = "10.1016/j.isci.2021.103353",
language = "English",
volume = "24",
pages = "1--15",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "11",
}
